Recording of calcium transient and analysis of calcium removal mechanisms in cardiac myocytes from rats and ground squirrels
文献类型: 外文期刊
第一作者: Wang, SQ
作者: Wang, SQ;Zhou, ZQ;Qian, H
作者机构:
关键词: cardiac cells;calcium transient;calcium removal;sarcoplasmic reticulum;hibernation;hypothermia;confocal laser-scanning microscopy
期刊名称:SCIENCE IN CHINA SERIES C-LIFE SCIENCES ( 影响因子:1.61; 五年影响因子:1.148 )
ISSN: 1006-9305
年卷期: 2000 年 43 卷 2 期
页码:
收录情况: SCI
摘要: With confocal microscopy, we recorded calcium transients and analyzed calcium removal rate at different temperatures in cardiac myocytes from the rat, a non-hibernator, and the ground squirrel, a hibernator. The results showed a remarkable increase of the diastolic level of calcium transients in the rat but no detectable change in the ground squirrel. Calcium transient of the ground squirrel, compared with that of the rat at the same temperature, had a shorter duration and showed a faster calcium removal. As indicated by the pharmacological effect of cyclopiazonic acid, calcium uptake by sarcoplasmic reticulum (SR) was the major mechanism of calcium removal, and was faster in the ground squirrel than in the rat. Our results confirmed the essential role of SR in hypothermia-tolerant adaptation, and negated the importance of Na-Ca exchange. We postulated the possibility to improve hypothermia-tolerance of the cardiac tissue of non-hibernating mammals.
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