Mung Bean Decreases Plasma Cholesterol by Up-regulation of CYP7A1

文献类型: 外文期刊

第一作者: Yao, Yang

作者: Yao, Yang;Hao, Liu;Shi, Zhenxing;Wang, Lixia;Cheng, Xuzhen;Wang, Suhua;Ren, Guixing

作者机构:

关键词: Cholesterol;CYP7A1;HMG-CoA reductase;Mung bean

期刊名称:PLANT FOODS FOR HUMAN NUTRITION ( 影响因子:3.921; 五年影响因子:4.223 )

ISSN: 0921-9668

年卷期: 2014 年 69 卷 2 期

页码:

收录情况: SCI

摘要: Our results affirmed that supplementation of 1 or 2 % mung bean could decrease plasma total cholesterol and triacylglycerol level. Mung bean increased mRNA 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Most importantly, mung bean increased not only the protein level of cholesterol-7 alpha-hydroxylase (CYP7A1) but also mRNA CYP7A1. It was concluded that the hypocholesterolemic activity of mung bean was most probable mediated by enhancement of bile acid excretion and up-regulation of CYP7A1.

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