Sex-specific thyroid disruption caused by phenanthrene in adult zebrafish (Danio rerio)
文献类型: 外文期刊
第一作者: Zhong, Liqiao
作者: Zhong, Liqiao;Wu, Luyin;Ru, Huijun;Wei, Nian;Yao, Fan;Ni, Zhaohui;Duan, Xinbin;Li, Yunfeng;Wu, Luyin;Zhang, He
作者机构:
关键词: Phenanthrene; Adult zebrafish; Thyroid disruption; Hypothalamic-pituitary-thyroid axis; Sex-specific
期刊名称:COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY ( 影响因子:4.52; 五年影响因子:4.203 )
ISSN: 1532-0456
年卷期: 2023 年 263 卷
页码:
收录情况: SCI
摘要: Polycyclic aromatic hydrocarbons (PAHs) are well-known contaminants with widespread distribution in envi-ronment and food. Phenanthrene is one of the most abundant PAHs in food and aquatic environment and generates reproductive and developmental toxicity in zebrafish. Nonetheless, whether phenanthrene caused sex -specific thyroid disruption in adult zebrafish is unclear. To determine this, adult zebrafish (male and female) were treated with phenanthrene (0, 0.85, 8.5, and 85 mu g/L) for 60 days. After the treatment period, we assessed the concentrations of thyroid hormones (THs) and expression levels of genes in the hypothalamic-pituitary -thyroid (HPT) axis. The results showed that phenanthrene exposure can lead to thyroid disruption in both male and female zebrafish. Exposure to phenanthrene dramatically reduced the levels of L-thyroxine (T4) and L-triiodothyronine (T3) in both male and female zebrafish, with a similar trend in both. However, the genes expression profiles of hypothalamic-pituitary-thyroid (HPT) axis were sex-specific. In all, the present study demonstrated that phenanthrene exposure could result in sex-specific thyroid disruption in adult zebrafish.
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