Thyroid-Disrupting Effects of Cadmium and Mercury in Zebrafish Embryos/Larvae
文献类型: 外文期刊
第一作者: Zhong, Liqiao
作者: Zhong, Liqiao;Wu, Luyin;Ru, Huijun;Wei, Nian;Yao, Fan;Ni, Zhaohui;Duan, Xinbin;Li, Yunfeng;Zhang, He
作者机构:
关键词: cadmium and mercury; hypothalamus-pituitary-thyroid axis; thyroid disruption; zebrafish
期刊名称:WATER ( 影响因子:3.4; 五年影响因子:3.5 )
ISSN:
年卷期: 2023 年 15 卷 1 期
页码:
收录情况: SCI
摘要: Cadmium (Cd2+) and mercury (Hg2+) are two kinds of non-essential heavy metals. Cd2+ and Hg2+ can cause thyroid disruption, but very few researchers have investigated the thyroid-disrupting effects of these metals on fish, specifically during their early developmental transition stage from embryos to larvae. In this study, wild-type zebrafish embryos were exposed to varying concentrations (contents) of Cd2+ (0, 10, 100, and 1000 mu g/L) and Hg2+ (0, 0.1, 1, and 10 mu g/L) for 120 h. Thereafter, the thyroid hormone contents and transcriptional changes in the genes, including thyroid stimulating hormone-beta (tsh beta), thyroglobulin (tg), sodium-iodide symporter (nis), thyroid peroxidase (tpo), transthyretin (ttr), thyroid hormone receptor-alpha and -beta (thr alpha, thr beta), types I and II iodothyronine deiodinase (dio1, dio2), and uridine diphosphate glucuronosyltransferase 1 family a, b (ugt1ab) associated with the hypothalamic-pituitary-thyroid (HPT) axis were measured. Results showed that zebrafish embryos/larvae malformation rates were significantly higher in the Cd2+ and Hg2+ groups. A significant increase in the thyroxine (T4) concentration and a decrease in the triiodothyronine (T3) concentration were observed in the Cd2+-exposed zebrafish embryos/larvae. On the other hand, the T4 and T3 concentrations were observed to be significantly increased after Hg2+ exposure. Additionally, changes were noted in the expression patterns of the HPT axis-linked genes after Cd2+ and Hg2+ exposure. Based on the results of the principal component analysis (PCA), it was concluded that Cd2+ exposure significantly affected the thyroid endocrine system at a concentration of 100 mu g/L, whereas Hg2+ exposure led to a thyroid disruption at a low concentration of 0.1 mu g/L. Thus, this study demonstrated that exposure to Cd2+ and Hg2+ metal ions induced developmental toxicity and led to thyroid disruption in zebrafish embryos/larvae.
分类号:
- 相关文献
作者其他论文 更多>>
-
ChIP-Seq analysis reveals PRKACB as a target gene of HOXC13 involved in rabbit hair follicle development
作者:Chen, Yang;Bao, Zhiyuan;Yao, Fan;Zhao, Bohao;Wu, Xinsheng;Liu, Yan
关键词:HOXC13; ChIP-Seq; PRKACB; Dermal papilla cells; Hair follicle
-
Sex-specific thyroid disruption caused by phenanthrene in adult zebrafish (Danio rerio)
作者:Zhong, Liqiao;Wu, Luyin;Ru, Huijun;Wei, Nian;Yao, Fan;Ni, Zhaohui;Duan, Xinbin;Li, Yunfeng;Wu, Luyin;Zhang, He
关键词:Phenanthrene; Adult zebrafish; Thyroid disruption; Hypothalamic-pituitary-thyroid axis; Sex-specific
-
Integrative genomic and transcriptomic analyses of a bud sport mutant ?Jinzao Wuhe? with the phenotype of large berries in grapevines
作者:Huang, Jianquan;Li, Yanhao;Zhang, He;Zhang, Na;Zhang, Guan;Lyu, Mingjie;Chen, Rui;Zhang, Guan;Li, Yanhao
关键词:Grapevine; Bud sport; Berry enlargement; Genetic variation; RNA-seq; WGRS
-
Changes in physical architecture and lipids compounds in skeletal muscle from Pekin duck and Liancheng white duck
作者:Tang, Hehe;Zhang, He;Liu, Dapeng;Li, Shunan;Wang, Zhen;Yu, Daxun;Guo, Zhan bao;Hou, Shuisheng;Zhou, Zhengkui
关键词:intramuscular fat; meat quality; muscle structure; lipid profile; lipidomics
-
MiMYB10 transcription factor regulates biosynthesis and accumulation of carotenoid involved genes in mango fruit
作者:Dang, Zhiguo;Zhu, Min;Chen, Huarui;Gao, Aiping;Ma, Weihong;Chen, Yeyuan;Dang, Zhiguo;Zhang, He;Zhu, Min;Chen, Yeyuan;Zhang, Ye;Wei, Yunxie
关键词:Mango; MYB10; Transcriptional regulation; Phytoene desaturase gene; Carotenoid; Peel color
-
Changes in nitrogen metabolism of phosphorus-starved bloom-forming cyanobacterium Microcystis aeruginosa: Implications for nutrient management
作者:Wei, Nian;Chen, Aifa;Zhang, Shubing;Li, Jie;Guo, Xiaohe;Song, Lirong;Gan, Nanqin;Zheng, Lingling;Jia, Yunlu;Li, Jie;Li, Jie
关键词:Bloom control; Dual reduction; Nitrogen uptake; Phosphorus deficiency; Phosphorus reduction; RNA-seq
-
Identification of key genes related to intramuscular fat deposition in Beijing-You chicken by mRNA and miRNA transcriptome analysis
作者:Gai, Kai;Ge, Yu;Zhang, He;Cong, Bailin;Guo, Shihao;Liu, Yizheng;Xing, Kai;Qi, Xiaolong;Wang, Xiangguo;Xiao, Longfei;Long, Cheng;Guo, Yong;Sheng, Xihui;Liu, Dapeng;Zhang, He;Chen, Li
关键词:intramuscular fat; Beijing-You chicken; transcriptome; miRNA; intramuscular fat; Beijing-You chicken; transcriptome; miRNA