Degradation of chondroitin sulfate: Mechanism of degradation, influence factors, structure-bioactivity relationship and application

文献类型： 外文期刊

第一作者： Wang, Kangyu

作者： Wang, Kangyu;Qi, Liwei;Zhao, Laiyu;Liu, Jiqian;Guo, Yujie;Zhang, Chunhui

作者机构：

关键词： Chondroitin sulfate; Degradation; Mechanism; Structure-bioactivity relationship; Application

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：11.2； 五年影响因子：10.2 ）

ISSN： 0144-8617

年卷期： 2023 年 301 卷

页码：

收录情况： SCI

摘要： Increasing studies focus on chondroitin sulfate (CS) degradation to improve its biological activity. The review mainly introduces the degradation methods of CS and their mechanisms. Studies have shown that different degradation methods can lead to different structures of low molecular weight chondroitin sulfate (LMCS). LMCS were prepared through f3-elimination reaction, hydrolysis reaction, hydrogen abstraction reaction, and deami-nation reaction. The degradation of CS is affected by two aspects: the structure of CS (disaccharide composition and molecular weight) and the influence of degradation conditions (temperature, pH, degradation promoters, auxiliary conditions, and time). LMCS with different structures have different biological activities. In addition, degradation could also change CS's metabolism, such as absorption effects and gut microbiota. Thus, choosing the appropriate degradation method for CS development and utilization is very important.

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