A pectic polysaccharide from fresh okra (Abelmoschus esculentus L.) beneficially ameliorates CCl4-induced acute liver injury in mice by antioxidation, inhibition of inflammation and modulation of gut microbiota
文献类型: 外文期刊
第一作者: Yan, Jing-Kun
作者: Yan, Jing-Kun;Zhu, Jie;Chen, Xu;Li, Longqing;Liu, Xiaozhen;Li, Lin;Yan, Jing-Kun;Wang, Chun;Chen, Ting -Ting;Zhang, Henan
作者机构:
关键词: Pectic polysaccharide; Acute liver damage; Gut microbiota; Hepatoprotection; Abelmoschus esculentus (Linn; ) Moench
期刊名称:FOOD AND CHEMICAL TOXICOLOGY ( 影响因子:5.572; 五年影响因子:5.692 )
ISSN: 0278-6915
年卷期: 2023 年 171 卷
页码:
收录情况: SCI
摘要: Okra [Abelmoschus esculentus (Linn.) Moench], as a well-known medicinal and food plant, has important phys-iological activities and health benefits, and polysaccharide is its main bioactive component. In this study, a pectic polysaccharide (OPS-50) prepared from fresh okra pods by three-phase partitioning and gradient (NH4)2SO4 precipitation at a saturation of 50% was employed in carbon tetrachloride (CCl4)-caused acute liver damage in mice to evaluate the hepatoprotective potential. Results indicated that OPS-50 was mainly composed of a limited linear homogalacturonan backbone and abundant rhamnogalacturonan-I domains as side chains. OPS-50 exerted positively protective effects on acute liver damage induced by CCl4 in mice through relieving weight reduction and organ damage, ameliorating liver function and dyslipidemia, alleviating oxidative stress, suppressing pro -inflammatory cytokines, modulating gut microbiota, and promoting short-chain fatty acid secretion. More-over, liver histopathology demonstrated the protective benefit of OPS-50 on CCl4-caused acute liver damage in mice. Therefore, our data suggested that the pectic OPS-50, as a dietary supplement, have great potential in preventing and treating chemical liver damages.
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