Genomic Analysis Reveals Candidate Genes Underlying Sex-Linked Eyelid Coloboma, Feather Color Traits, and Climatic Adaptation in Huoyan Geese

文献类型： 外文期刊

第一作者： Wen, Junhui

作者： Wen, Junhui;Zhang, Li;Gu, Hongchang;Wen, Junhui;Zhao, Xiurong;Zhang, Xinye;Ren, Xufang;Wang, Gang;Chen, Anqi;Qu, Lujiang;Yu, Jincheng;Li, Haiying;Wang, Huie;Wang, Huie

作者机构：

关键词： goose; eyelid coloboma; feather color; climate adaptation; genome

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2023 年 13 卷 23 期

页码：

收录情况： SCI

摘要： Simple Summary Huoyan geese are found in the cold regions of Northern China and have two specific traits. To understand the genetic basis of these traits, i.e., upper eyelid coloboma and gosling feather color, as well as their adaptation to the climate, we used whole-genome resequencing technology to analyze Huoyan geese and local geese from Southern China with different traits. By performing this analysis, we identified candidate genes associated with upper eyelid coloboma and gosling feather color, as well as genes related to climate adaptation in geese. These findings provide valuable insights for the selection of goose breeds.Abstract Driven by natural and artificial selection, the domestic Huoyan geese from Northern China have gradually generated specific phenotypes and climatic adaptations. To understand the genetic basis of the two specific phenotypes that are sex linked, including upper eyelid coloboma and gosling feather color, as well as the climatic adaptations of the Huoyan goose, which can contribute to the artificial selection and breeding of geese. We selected Huoyan geese and nine Southern Chinese goose breeds and identified their divergence on the genomic level. Using selective sweep analysis, we found that PTPRM on chromosome Z influences the upper eyelid coloboma phenotype of the Huoyan goose, and TYRP1 is a plausible candidate gene for the Huoyan gosling feather color. We obtained a number of genes related to cold adaptation in Huoyan geese, mainly involved in physiological functions such as metabolism, angiogenesis contraction and circulatory system, apoptosis, immunity, stress, and neural system. The most interesting candidates for cold adaptation are PIP5K1B and NMNAT3 that are associated with energy metabolism and stress. We also obtained some genes related to heat adaptation, including AGTPBP1, associated with neurology; GDA, associated with skin pigmentation; and NAA35, associated with apoptosis. These findings deepen our understanding of the genetics of specific phenotypes and climate adaptation in local geese and provide insights for the selection of goose breeds.

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