文献类型： 外文期刊
第一作者： Xu, Y. L.
作者： Xu, Y. L.;Zhang, Y. D.;Wang, Z. P.;Wang, T.;Rong, S.;Chen, W. W.;Fan, C.;Wang, T.;Xu, J. Q.
作者机构：
关键词： sesamol; Alzheimer's disease; cognition; SIRT1; BDNF
期刊名称：ACTA ALIMENTARIA （ 影响因子：1.1； 五年影响因子：1.0 ）
ISSN： 0139-3006
年卷期： 2023 年 52 卷 2 期
页码：
收录情况： SCI
摘要： To explore the effect of sesamol on the cognition of APP/PS1 mice, 8-week-old APP/PS1 and wild-type male mice were divided into AD model group, AD + sesamol (50 mg kg-1 bw) group, and Control group. Sesamol was orally administered once a day for 5 months. Morris water maze was used to evaluate the learning and memory ability of mice. The number of synapses in the hippocampal neurons was detected by Golgi staining. Nissl staining was used to observe the changes of Nissl bodies in CA1 and CA3 regions of the hippocampus. Western blotting was used to detect the expression of A & beta;, SIRT1, BDNF, and p-CREB/ CREB in the hippocampus and cortex. Compared with the model group, sesamol decreased the latency period of APP/PS1 mice (P < 0.05) and increased the total number of neuronal dendritic spines in the hippocampal CA3 region, as well as increased the number of Nissl bodies (P < 0.05). Western blotting results showed that sesamol significantly reduced A & beta; protein expression in the hippocampus and cortex, increased SIRT1 expression in the cortex, and increased BDNF expression in the hippocampus (P < 0.05). Sesamol improved the learning and memory abilities of APP/PS1 mice probably through increasing the density of neuronal dendritic spines and upregulating the levels of SIRT1 and BDNF.
分类号：
- 相关文献
作者其他论文 更多>>
-
Pathogenic infection characteristics and risk factors for bovine respiratory disease complex based on the detection of lung pathogens in dead cattle in Northeast China
作者：Zhou, Y.;Dai, G.;Li, X.;Xiang, Y.;Jiang, S.;Zhang, Z.;Zhu, Z.;Fan, C.;Zhou, Y.;Zhou, Y.;Shao, Z.;Ren, Y.;Zhang, G.
关键词：bovine respiratory disease complex; necropsy; pathogen detection; epidemiological investigation
-
GENETIC DIVERSITY AND POPULATION STRUCTURE OF THE ASIAN HOUSE RAT RATTUS TANEZUMI IN SHANXI, CHINA
作者：Yang, X.;Guo, H.;Zhang, M.;Ren, Z.;Zhang, J.;Yang, X.;Wang, T.;Yang, J.;Zou, B.;Zhang, J.;Zhang, J.
关键词：Diversity; Population structure; Asian house rat; Gnomic analysis; Microsatellite loci; COI gene sequence
-
Identification of Colletotrichum liriopes as the Causative Agent of Anthracnose in Buckwheat (Fagopyrum esculentum) in China
作者：Chen, T. X.;Wang, T.;Gou, Y. D.;Li, C. J.;Chen, T. X.;Wang, T.;Gou, Y. D.;Li, C. J.;Chen, T. X.;Wang, T.;Gou, Y. D.;Li, C. J.;Chen, T. X.;Wang, T.;Gou, Y. D.;Li, C. J.;Wang, L. H.
关键词：Colletotrichum liriopes; Fagopyrum esculentum; anthracnose
-
Hepatic transcriptome perturbations in dairy cows fed different forage resources
作者：Gao, S. T.;Ma, Lu;Zhang, Y. D.;Wang, J. Q.;Bu, D. P.;Loor, J. J.;Loor, J. J.
关键词：Liver transcriptome; Forage resources; RNAseq; Corn Stover
-
Short communication: Decrease of lipid profiles in cow milk by ultra-high-temperature treatment but not by pasteurization
作者：Xu, Q. B.;Zhang, Y. D.;Zheng, N.;Wang, Q.;Li, S.;Zhao, S. G.;Wen, F.;Meng, L.;Wang, J. Q.;Xu, Q. B.
关键词：cow milk; lipidomics; pasteurized treatment; UHT treatment
-
Warm winter temperature induced changes in the dormant buds of 'Dangshansuli' pear (Pyrus bretschneideri Rehd.)
作者：Yi, X. K.;Xu, Y. L.;Gao, Z. H.;Zhang, J. Y.;Pan, H. F.;Qi, Y. J.;Qin, G. H.;Li, Bo;Xu, Y. L.;Li, Bo
关键词：Endogenous hormones; pear; bud dormancy; winter warming
-
First Report of Powdery Mildew Caused by Podosphaera xanthii on Okra in China.
作者：Fan, C.;Cui, H.;Ding, Z.;Gao, P.;Luan, F.;Fan, C.;Cui, H.;Ding, Z.;Gao, P.;Luan, F.;Fan, C.
关键词：
