Development and Immunoprotection of Bacterium-like Particle Vaccine against Infectious Bronchitis in Chickens
文献类型： 外文期刊
作者： Zhang, Pengju 1 ; Yang, Tiantian 2 ; Sun, Yixue 3 ; Qiao, Haiying 1 ; Hu, Nianzhi 1 ; Li, Xintao 1 ; Wang, Weixia 1 ; Zhang, Lichun 1 ; Cong, Yanlong 2 ;
作者机构： 1.Jilin Acad Agr Sci, Inst Anim Biotechnol, Changchun 130033, Peoples R China
2.Jilin Univ, Coll Vet Med, Lab Infect Dis, Key Lab Zoonosis Res,Minist Educ, Changchun 130062, Peoples R China
3.Changchun Univ, Dept Pol & Regulat, Changchun 130022, Peoples R China
关键词： infectious bronchitis virus; S1 subunit; bacterium-like particles; immunoprotective
期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）
ISSN：
年卷期： 2023 年 11 卷 8 期
页码：
收录情况： SCI
摘要： Infectious bronchitis (IB) is a major threat to the global poultry industry. Despite the availability of commercial vaccines, the IB epidemic has not been effectively controlled. The exploration of novel IBV vaccines may provide a new way to prevent and control IB. In this study, BLP-S1, a bacterium-like particle displaying the S1 subunit of infectious bronchitis virus (IBV), was constructed using the GEM-PA surface display system. The immunoprotective efficacy results showed that BLP-S1 can effectively induce specific IgG and sIgA immune responses, providing a protection rate of 90% against IBV infection in 14-day-old commercial chickens. These results suggest that BLP-S1 has potential for the development of novel vaccines with good immunogenicity and immunoprotection.
- 相关文献
作者其他论文 更多>>
-
Long non-coding RNA NEAT1 promotes mouse granulosa cell proliferation and estradiol synthesis by sponging miR-874-3p
作者：Zhang, Pengju;Wang, Weixia;Tan, Chengcheng;Liu, Xiaohui;Li, Xintao;Zhang, Lichun;Gao, Jinliang;Lin, Shan;Lin, Guangyu;Li, Xintao;Zhang, Lichun
关键词：long non-coding RNA; nuclear-enriched abundant transcript 1; mouse granulosa cell; apoptosis; estradiol synthesis
-
Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep
作者：Jia, Qi;Zhang, Shuangshuang;Liu, Jianqiang;Luo, Xinhui;Liu, Yu;Li, Xin;Zhang, Lichun;Jia, Qi;Zhang, Shuangshuang;Wang, Dan;Sun, Fuliang;Xia, Guangjun
关键词：fibroblast growth factor 9; small-tailed Han sheep; dermal papilla cells; proliferation
-
Microsatellite Genome-Wide Database Development for the Commercial Blackhead Seabream (Acanthopagrus schlegelii)
作者：Luo, Xinhui;Zhang, Lichun;Luo, Xinhui;Chen, Songlin;Luo, Xinhui;Chen, Songlin
关键词：microsatellite database; genome-wide; whole genome resequencing; Acanthopagrus schlegelii
-
Transcript variants of long-chain acyl-CoA synthase 1 have distinct roles in sheep lipid metabolism
作者：Cao, Yang;Yu, Yongsheng;Zhang, Lichun;Liu, Yu;Jin, Haiguo;Liu, Lixiang;Cao, Yang;Zheng, Kaizhi;Wang, Sutian
关键词：ACSL1; transcript variants; sheep; APA; lipid metabolism
-
Comment on: Rabies-infected dogs at slaughterhouses: A potential risk of rabies transmission via dog trading and butchering activities in Vietnam
作者：Cong, Yanlong;Li, Junfeng;Wang, Fengjie;Sun, Yixue;Zhao, Lifeng;Guo, Li;Xue, Honghong;Wang, Yongzhi;Li, Xiaocheng;Liu, Xuelian;Zhao, Jinghui;Li, Xiaocheng;Liu, Xuelian;Zhao, Jinghui
关键词：
-
Complete genome analysis of the newly isolated Shigella sonnei phage vB_SsoM_Z31
作者：Wei, Bingdong;Zhang, Lichun;Zheng, Lin;Chen, Long;Yu, Wei;Wei, Bingdong;Xu, Yongping;Wei, Bingdong;Zheng, Lin;Chen, Long;Yu, Wei;Cong, Cong;Xu, Yongping
关键词：
-
Preparation of Pseudo-typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity
作者：Chang, Xiaoyan;Zhou, Keru;Liu, Yanguang;Wang, Guiqin;Liu, Yanguang;Zhang, Lichun;Duan, Lian;Zhang, Guoliang;Wang, Haikun
关键词：
