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Antioxidative and hepatoprotective activities of a novel polysaccharide (LSAP) from Lepista sordida mycelia

文献类型： 外文期刊

作者： Xu, Yingyin 1 ; Li, Yuanhui 2 ; Lu, Yuxiao 3 ; Feng, Xiaobin 2 ; Tian, Guoting 4 ; Liu, Qinghong 2 ;

作者机构： 1.Sichuan Acad Agr Sci, Soil & Fertilizer Res Inst, Chengdu 610066, Peoples R China

2.China Agr Univ, Coll Hort, Dept Vegetables, Beijing 100193, Peoples R China

3.Tangshan Coll, Dept Environm & Chem Engn, Tangshan 063000, Peoples R China

4.Yunnan Acad Agr Sci, Inst Biotechnol & Germplasm Resource, Kunming 650223, Yunnan, Peoples R China

关键词： Lepista sordida; Polysaccharide; Antioxidant activity; Hepatoprotective effects

期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：5.154； ）

ISSN：

年卷期： 2021 年 10 卷 4 期

页码：

收录情况： SCI

摘要： A novel alkali-soluble polysaccharide from Lepista sordida (LSAP) mycelia with antioxidative and hepatoprotective activities was characterized. The weight-average molecular weight and number-average molecular weight of LSAP were 1.442 x 10(3) and 6.05 x 10(2) kDa, respectively. LSAP was consisted of glucose (57.9%), xylose (31.8%), and small amounts of rhamnose, arabinose, galactose, glucuronic acid, and galacturonic acid (1.2%-3.1%). The FT-IR and 2D NMR confirmed that LSAP was composed of Xylp, Araf, 4-O-Me-alpha-D-GlcpA, (1 -> 4)-linked beta-D-Glcp, and (1 -> 4)-alpha-D-GalA, and beta-glycosidic linkages between these sugar units. LSAP displayed notable effects on 1,1-dephenyl-2-picryhydrazyl (DPPH) radical scavenging, hydrogen peroxide scavenging, lipid peroxidation inhibitory ability, reducing power and Fe2+ chelating property. These biological effects were further verified by suppressing CCl4-induced oxidative liver damage in mice at doses of 100 and 200 mg/kg. Administration of LSAP in mice prior to CCl4 significantly prevented the CCl4-induced elevation in serum alanine aminotransferase, aspartate aminotransferase, and hepatic malondialdehyde. Mice treated with LSAP demonstrated to increase activities in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the liver. We also found out that LSAP prevented CCl4-induced oxidative liver histological alteration. LSAP may exert hepatoprotective effects against CCl4-induced damage through antioxidant mechanisms in model mice. (C) 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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