您好，欢迎访问上海市农业科学院 机构知识库！
上海市农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

A novel calcium-binding peptide from bovine bone collagen hydrolysate and chelation mechanism and calcium absorption activity of peptide-calcium chelate

文献类型： 外文期刊

作者： Qi, Liwei 1 ; Zhang, Hongru 1 ; Guo, Yujie 1 ; Zhang, Chunhui 1 ; Xu, Yang 3 ;

作者机构： 1.Chinese Acad Agr Sci, Minist Agr & Rural Affairs, Inst Food Sci & Technol, Key Lab Agroprod Proc, Beijing 100193, Peoples R China

2.Univ Liege Gembloux Agrobio Tech, Lab Biomass & Green Technol, Passageportes 2, B-5030 Gembloux, Belgium

3.Inner Mongolia Mengtai Biol Engn Co Ltd, Shengle Econ Pk, Helinger Cty, Hohhot 010000, Inner Mongolia, Peoples R China

关键词： Calcium-binding peptide; Calcium-sensing receptor; Chelation mechanism; Caco-2 cells

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2023 年 410 卷

页码：

收录情况： SCI

摘要： A novel calcium-binding peptide from bovine bone collagen hydrolysate was screened based on a new tar-get-the calcium-sensing receptor (CaSR), and its chelation mechanism and calcium absorption activity were investigated. Glu-Tyr-Gly exhibited superior binding affinities to CaSR because of its interaction with the active sites of the CaSR Venus Flytrap (VFT) domain. Glu-Tyr-Gly-Ca may exist in five potential chelation modes and its potential chelation mechanism was that calcium ions were located in the center and surrounded by ionic bonds (carboxyl group) and coordination bonds (carbonyl, amino, and carboxyl group). Glu-Tyr-Gly-Ca was slightly damaged in the intestinal fluid and at different temperatures, whereas it was severely damaged in the gastric fluid and acidic conditions. The results of the calcium dialysis percentage and Caco-2 cells experiments showed that Glu-Tyr-Gly-Ca possessed good calcium transport activity and bioavailability. The findings provided theo-retical basis for Glu-Tyr-Gly-Ca as potential calcium supplement to improve intestinal calcium absorption.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：上海市农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台