Chondroitin sulfate stimulates the secretion of H2S by Desulfovibrio to improve insulin sensitivity in NAFLD mice
文献类型： 外文期刊
作者： Chen, Long 2 ; Gao, Yansong 1 ; Zhao, Yujuan 1 ; Yang, Ge 1 ; Wang, Chao 1 ; Zhao, Zijian 1 ; Li, Shengyu 1 ;
作者机构： 1.Jilin Acad Agr Sci, Inst Agr Prod Proc Technol, Natl R&D Ctr Milk Proc, Changchun 130033, Peoples R China
2.Jilin Acad Agr Sci, Inst Anim Nutr & Feed, Changchun 130033, Peoples R China
关键词： NAFLD; Chondroitin sulfate; Gut-liver axis; Desulfovibrio; Hydrogen sulfide; Insulin resistance
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）
ISSN： 0141-8130
年卷期： 2022 年 213 卷
页码：
收录情况： SCI
摘要： Hydrogen sulfide (H2S) is a bioactive gas regulating insulin secretion and sensitivity, produced by sulfatereducing bacteria in the gut. The present study investigated the effect of chondroitin sulfate (CS) treatment, which indirectly increased the H2S production on nonalcoholic fatty liver disease (NAFLD). A 7-week CS supplementation had beneficial effects on body weight gain, liver function, hepatic histology, and serum lipid levels. CS could ameliorate diet-induced insulin resistance and improve insulin sensitivity via the AKT pathway, and modulate gut microbiota composition, especially increased the abundance of Desulfovibrio and elevated levels of hydrogen sulfide (H2S). Collectively, these findings suggested that CS treatment was positively correlated with Desulfovibrio in the gut, and the metabolic H2S flowed into the liver via the gut-liver axis, thereby triggering the AKT signaling pathway and improving insulin resistance. Thus, CS-induced alterations in the gut microbiota seem a promising for ameliorating NAFLD.
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