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Molecular and functional characterization of the retinol-binding protein 4 (RBP4) in hepatocytes of Schizothorax prenanti in response to palmitic acid

文献类型： 外文期刊

作者： Wang, Yan 1 ; Zhu, Peng 1 ; Ni, Jiahui 1 ; Mo, Qilang 1 ; Luo, Wei 1 ; Du, Zongjun 1 ; Jiang, Jun 1 ; Yang, Song 1 ; Zhao, Liulan 1 ; Gong, Quan 2 ;

作者机构： 1.Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Sichuan, Peoples R China

2.Sichuan Acad Agr Sci, Fisheries Inst, Chengdu 611713, Sichuan, Peoples R China

关键词： S; prenanti; RBP4; Hepatocyte; Palmitic acid; Lipid metabolism

期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：3.014； 五年影响因子：3.187 ）

ISSN： 0920-1742

年卷期： 2022 年 48 卷 2 期

页码：

收录情况： SCI

摘要： Retinol-binding protein 4 (RBP4) protein is a kind of adipokines synthesized and secreted by the liver, which has been verified to play important roles in liver metabolism and energy homeostasis. However, the effects of RBP4 on hepatic lipid accumulation are still elusive in fish. In the present study, we cloned and characterized the RBP4 gene in Schizothorax prenanti (S. prenanti). RBP4 gene was specifically expressed in the liver and abdominal adipose tissue. Palmitic acid (PA; 400 mu M) can significantly increase lipid deposition in primary hepatocytes after 12 h of treatment. Furthermore, RBP4 knockdown can relieve the excessive lipid deposition and endoplasmic reticulum stress in the hepatocytes caused by PA. The inhibition of RBP4 abolished the ability of PA to induce the expression of genes involved in lipogenesis and endoplasmic reticulum stress. These results demonstrate that RBP4 inhibition attenuated PA-induced lipid deposition and endoplasmic reticulum stress in hepatocytes of S. prenanti. This study could contribute to improve the understanding of RBP4 functions in the PA-induced lipid deposition in hepatocytes of fish.

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