PAYCS Alleviates Scopolamine-Induced Memory Deficits in Mice by Reducing Oxidative and Inflammatory Stress and Modulation of Gut Microbiota-Fecal Metabolites-Brain Neurotransmitter Axis
文献类型: 外文期刊
作者: Zhao, Tiantian 1 ; Zhong, Saiyi 2 ; Xu, Jucai 3 ; Jiao, Wenjuan 1 ; Liu, Weifeng 1 ; Huang, Lihua 4 ; Zhang, Yehui 1 ; Zhang, Yousheng 1 ;
作者机构: 1.Guangdong Acad Agr Sci, Sericulture & Agri Food Res Inst, Key Lab Funct Foods, Minist Agr & Rural Affairs,Guangdong Key Lab Agr, Guangzhou 510610, Peoples R China
2.Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China
3.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
4.Guangzhou City Polytech, Dept Food, Guangzhou 510405, Peoples R China
关键词: peptides; scopolamine; gut microbiota; fecal metabolites; brain neurotransmitters
期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.895; 五年影响因子:6.048 )
ISSN: 0021-8561
年卷期: 2022 年 70 卷 9 期
页码:
收录情况: SCI
摘要: The bioactive peptide PAYCS (Pro-Ala-Tyr-Cys-Ser) identified from anchovy hydrolysates has been reported to be positive in memory alleviation. The gut microbiota-brain axis plays a vital role in brain functions, which could be affected by nutritional supplementation. Herein, we found that PAYCS at different concentrations (PAYCS-L and PAYCS-H) showed various improving effects in behavioral tests and alleviation effects on oxidative as well as inflammatory stress in the scopolamine-induced AD mouse model. The 16S rRNA results illustrated that PAYCS-L altered the ratio of Bacteroidetes/Firmicutes and PAYCS treatment elevated the relative abundance of Cacteroidaceae and Prevotellaceae. Notably, administration of PAYCS significantly upregulated memory-related metabolites and neurotransmitters. Overall, PAYCS-L reversed memory deficits of amnesiac mice partially via the modulation of gut microbiota-metabolites-brain neurotransmitter axis. For PAYCS-H, functions might be involved in the reversal of oxidative and inflammatory impairments in the liver and serum, which was also associated with the changed intestinal microbiota and fecal metabolites.
- 相关文献
作者其他论文 更多>>
-
Formulation and stabilization of high internal phase emulsions via mechanical cellulose nanofibrils/ethyl lauroyl arginate complexes
作者:Huang, Luyao;Xu, Chuan;Gao, Wenhua;Guo, Shasha;Li, Jun;Rojas, Orlando J.;Jiao, Wenjuan;Jiao, Wenjuan
关键词:Cellulose nanofibrils; Ethyl lauroyl arginate; High internal phase emulsions; 3D printing
-
Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis
作者:Lin, Yilin;Wang, Ruifei;Li, Xiaoqing;Addo, Keren Agyekumwaa;Fang, Meimei;Yu, Yigang;Zhang, Yehui;Yu, Yigang
关键词:Kojic acid; Tea polyphenols; Antibacterial mechanism; RNA-seq; Escherichia coli O157:H7
-
Effects of walnut seed coat polyphenols on walnut protein hydrolysates: Structural alterations, hydrolysis efficiency, and acetylcholinesterase inhibitory capacity
作者:Su, Guowan;Chen, Jieqiong;Huang, Lin;Zhao, Mouming;Zhang, Jianan;Deng, Liuxin;Chen, Jieqiong;Zhang, Yehui;Zhao, Tiantian;Huang, Qingrong;Zhao, Tiantian;Zhao, Mouming;Zhao, Tiantian;Zeng, Xi
关键词:Walnut hydrolysates; Seed coat polyphenols; Structural alterations; Hydrolysis efficiency; AChE inhibition; Synergistic effects
-
Effects of polyvinyl alcohol content and hydrolysis degree on the structure and properties of extruded starch-based foams
作者:Liu, Fengsong;Zhang, Yan;Xiao, Xinglong;Cao, Yifang;Bai, Hong;Yu, Long;Duan, Qingfei;Jiao, Wenjuan
关键词:Starch-based foam; Foaming ratio; Viscoelastic properties; Mechanical properties; Water resistance
-
Impact of ternary NADES prepared from proline, glucose and water on the Maillard reaction: Reaction activity, Amadori compound yield, and taste-enhancing ability
作者:Su, Guowan;Yu, Zixiang;Wang, Huayang;Zhao, Mouming;Zhang, Jianan;Su, Guowan;Yu, Zixiang;Wang, Huayang;Zhao, Mouming;Zhang, Jianan;Zhao, Tiantian;Zhang, Jianan
关键词:Maillard reaction; Amadori rearrangement product; Umami-enhancing; Saltiness-enhancing; Natural deep eutectic solvents (NADES)
-
The Umami-enhancing Ability Improvement of Pea Protein Hydrolysate by Maillard Reaction Utilizing Sugar-derived NADES
作者:Wang, Huayang;Liu, Tongxun;Su, Guowan;Zhao, Mouming;Zhang, Jianan;Wang, Huayang;Liu, Tongxun;Su, Guowan;Zhao, Mouming;Zhang, Jianan;Zhao, Tiantian
关键词:Pea protein hydrolysate; Maillard reaction; Peptide; umami-enhancing; NADES
-
Exploring the Release of Elastin Peptides Generated from Enzymatic Hydrolysis of Bovine Elastin via Peptide Mapping
作者:Zhang, Jianan;Su, Guowan;Zhao, Mouming;Zhang, Jianan;Su, Guowan;Zhao, Mouming;Liu, Yang;Jiang, Liwen;Zhao, Tiantian
关键词:elastin peptides; 2D LC-MS; peptide fingerprinting; enzymatic cleavage patterns; elastase inhibitory activity