1Discovery of Azo-Aminopyrimidines as Novel and Potent Chitinase Of Chi-h Inhibitors via Structure-Based Virtual Screening and Rational Lead Optimization

作者： Dong, Lili; Liu, Yaxin; Li, Jingjing; Wang, Yizhen; Shi, Jiakun; Liu, Jiaxin; Ma, Shujie; Zhang, Lihui; Dong, Jingao; Jiang, Xi; Chen, Wei; Yang, Qing; Jiang, Xi; Yang, Qing; Shen, Shengqiang; SCI

机构： Hebei Agr Univ, Coll Plant Protect, State Key Lab North China Crop Improvement & Regul, Baoding 071001, Peoples R China; Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr, Shenzhen 518120, Peoples R China; Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100091, Peoples R China;

来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

关键词： virtual screening; aminopyrimidine derivatives; chitinase; Of Chi-h; inhibitor; insecticidal activity

2Identification of Triazolo-quinazolinone Derivatives as Novel and Potent Chitinase OfChi-h Inhibitors Based on Structure-Based Virtual Screening

作者： Dong, Lili; Ding, Baokang; Yang, Meiling; Liu, Yaxin; Chen, Ziyang; Cao, Qingnan; Gao, Yongming; Ma, Shujie; Zhang, Lihui; Dong, Jingao; Jiang, Xi; Chen, Wei; Yang, Qing; Shen, Shengqiang; Jiang, Xi; Yang, Qing; SCI

机构： Hebei Agr Univ, Coll Plant Protect, State Key Lab North China Crop Improvement & Regul, Baoding 071001, Hebei, Peoples R China; Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing 100193, Peoples R China; Tingo Exosomes Technol Co Ltd, Tianjin 300301, Peoples R China; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr, Shenzhen 518120, Peoples R China;

来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

关键词： triazolo-quinazolinone; chitinase; OfChi-h; Ostrinia furnacalis; virtual screening

年份：2023

3Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1

作者： Chen, Wei; Chen, Qi; Yang, Qing; Kumar, Ashutosh; Zhang, Kam Y. J.; Jiang, Xi; Yang, Qing; Yang, Qing; SCI

机构： Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China; RIKEN, Lab Struct Bioinformat, Ctr Biosyst Dynam Res, Yokohama, Kanagawa 2300045, Japan; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch, Shenzhen, Peoples R China; Dalian Univ Technol, Sch Bioengn, Dalian, Peoples R China;

来源：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

关键词： Nematode chitinase; inhibitor; inhibitory mechanism; structural optimisation

年份：2021

4Crystal Structure and Structure-Based Discovery of Inhibitors of the Nematode Chitinase CeCht1

作者： Chen, Qi; Chen, Wei; Yang, Qing; Kumar, Ashutosh; Janezic, Matej; Zhang, Kam Y. J.; Jiang, Xi; Yang, Qing; SCI

机构： Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China; RIKEN, Lab Struct Bioinformat, Ctr Biosyst Dynam Res, Yokohama, Kanagawa 2300045, Japan; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch, Shenzhen 518120, Peoples R China;

来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

关键词： nematode chitinase; crystal structure; chitinase inhibitor; virtual screening; nematicide

年份：2021

5Glycoside hydrolase family 18 chitinases: The known and the unknown

作者： Chen, Wei; Yang, Qing; Yang, Qing; Jiang, Xi; Yang, Qing; SCI

机构： Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, 2 West Yuanmingyuan Rd, Beijing 100193, Peoples R China; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch, 7 Pengfei Rd, Shenzhen 518120, Peoples R China; Dalian Univ Technol, Sch Bioengn, 2 Linggong Rd, Dalian 116024, Peoples R China;

来源：BIOTECHNOLOGY ADVANCES

关键词： Chitinase; Glycoside hydrolase; Physiological function; Crystal structure; Catalytic mechanism; Inhibitor

年份：2020