Physical and Biological Investigation of Injectable Thai Silk Fibroin/Hyaluronic Acid Hydrogel Sustained-Releasing Dexamethasone
文献类型: 会议论文
第一作者: Thapakorn Pankoh
作者: Thapakorn Pankoh 1 ; Rath Itthipanichpong 2 ; Juthamas Ratanavaraporn 3 ;
作者机构: 1.Biomedical Engineering Program Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand
2.Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
3.Biomedical Engineering Program, Biomedical Engineering Research Center, Biomaterial Engineering for Medical and Health Research Unit Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand
关键词: Glaucoma;Drugs;Hydrogels;Surgery;Manuals;Fibroblasts;Wounds
会议名称: Biomedical Engineering International Conference
主办单位:
页码: 1-5
摘要: Failure of glaucoma surgery occurred due to fibrosis formation. To prevent fibrosis formation, an anti-inflammation agent, such as dexamethasone (DEX), was utilized to inhibit inflammation during the wound healing process, leading to fibrosis reduction. In the present study, DEX is loaded into an ultrasonication-induced silk fibroin/hyaluronic acid (SF/HA) hydrogel as a sustained-release drug delivery system. The SF/HA hydrogel can be fabricated using ultrasonic induction resulting to homogeneous gel within 1 day after incubation at 37°C. For injectability test, the results confirmed that the hydrogel could be easily injected through the 30-gauge needle, particularly for hydrogel containing less concentration and higher HA content. Furthermore, The SF/HA hydrogel showed non-swelling ability, released DEX up to 60% along 30 days of incubation in balanced salt solution, and non-cytotoxic to fibroblasts. However, these properties of the SF/HA hydrogels are independent of their concentrations and SF/HA ratios. As aforementioned, the ultrasonication-induced SF/HA hydrogel could be utilized as an injected carrier of DEX for incorporation with postoperative glaucoma surgery to reduce inflammation and fibrosis formation.
分类号: r318-53
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