文献类型： 会议论文
第一作者： M. E. Moncada
作者： M. E. Moncada 1 ; C. P. Ossa-Orozco 2 ; M. L. Mejia 1 ;
作者机构： 1.Metropolitan Technological Institute (ITM),Advanced Materials and Energy (MATyER), Faculty of Engineering,Medellin,Colombia
2.University of Antioquia,Biomaterials Research Group, Faculty of Engineering,Medellin,Colombia
关键词： Nanoparticles;Water;Silver;Bone tissue;Nanocomposites;Surface morphology;Stability analysis
会议名称： Annual International Conference of the IEEE Engineering in Medicine and Biology Society
主办单位：
页码： 1176-1180
摘要： In this work, electrospinning was used for the preparation of composite nanofibrous scaffold, of polyvinyl alcohol (PVA), silk fibroin (SF) extract of Bombyx mori cocoons and silver nanoparticles (Ag NPs), as a substrate for bone tissue engineering. The PVA pristine was prepared at a concentration of 10% wt. The composite nanofibers scaffolds of PVA was prepared with silk fibroin and silver nanoparticles, in relation of PVA: SF (90:10) (v/v) respectively. The formation and presence of AgNPs was confirmed by ultraviolet-visible spectroscopy (Uv-vis). The diameter distribution of the nanofibers was narrow by SEM using Image J software. The chemical composition was determined by FTIR spectra. The wettability was determined using water contact angle. The results showed the average nanofiber diameter of PVA10 pristine was 108.18 nm and to PVA10/SF/Ag NPs was 106.62 nm, no significant changes were noted in the mean diameter, but there were changes in its morphology. The average nanofiber diameter increase with the concentration of PVA at PVA15/SF/Ag NPs was 189.12 nm to PVA18/SF/Ag NPs was 224,23 nm. FTIR spectra indicated characteristic absorption peaks related to the chemical structure of PVA, fibroin and Ag NPs, it demonstrated good interactions between them, caused by strong intermolecular hydrogen bonds. The contact angle of the scaffolds PVA 10%wt decrease with the incorporation of fibroin and show hydrophilic characteristics. The achievements indicate the potential of the nanofibers of PVA15/SF/Ag NPs as a possible substitute for bone tissue engineering.Clinical Relevance—This establishes a possible substrate of PVA/SF/Ag NPs that exhibit desired properties such as porosity and high surface area to volume ratio for bone tissue engineering.
分类号： q81-53
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Poly (vinyl alcohol)/Silk Fibroin/Ag NPs composite nanofibers for bone tissue engineering
作者：M. L. Mejia;M. E. Moncada;C. P. Ossa-Orozco
关键词：Silver nanoparticles;Bone tissue engineering;Composite nanofibers;Polyvinyl alcohol (PVA);Silk fibroin
