您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Linear Mixed Effects Modelling of Oxygen Desaturation after Sleep Apneas and Hypopneas: A Pilot Study

文献类型： 会议论文

第一作者： Jordi Solà-Soler

作者： Jordi Solà-Soler 1 ; Beatriz F. Giraldo 1 ; Raimon Jané 1 ;

作者机构： 1.Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Science and Technology (BIST), Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) and ESAII Department, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Barcelona, Spain

关键词： Effects Modelling;Oxygen Desaturation;Sleep Apneas

会议名称： International Conference of the IEEE Engineering in Medicine and Biology Society

主办单位：

页码： 5731-5734

摘要： Obstructive Sleep Apnea severity is commonly determined after a sleep polysomnographic study by the Apnea-Hypopnea Index (AHI). This index does not contain information about the duration of events, and weights apneas and hypopneas alike. Significant differences in disease severity have been reported in patients with the same AHI. The aim of this work was to study the effect of obstructive event type and duration on the subsequent oxygen desaturation (SaO_2) by mixed-effects models. These models allow continuous and categorical independent variables and can model within-subject variability through random effects. The desaturation depth dSaO_2, desaturation duration dtSaO_2 and desaturation area SaO_2A were analyzed in the 2022 apneas and hypopneas of eight severe patients. A mixed-effects model was defined to account for the influence of event duration (AD), event type, and their interaction on SaO_2 parameters. A two-step backward model reduction process was applied for random and fixed effects optimization. The optimum model obtained for dtSaO_2 suggests an almost subject-independent proportional increase with AD, which did not significantly change in apneas as compared to hypopneas. The optimum model for dSaO_2 reveals a significantly higher increase as a function of AD in apneas than hypopneas. Dependence of dSaO_2 on event type and duration was different in every subject, and a subject-specific model could be obtained. The optimum model for SaO_2A combines the effects of the other two. In conclusion, the proposed mixed-effects models for SaO_2 parameters allow to study the effect of respiratory event duration and type, and to include repeated events within each subject. This simple model can be easily extended to include the contribution of other important factors such as patient severity, sleep stage, sleeping position, or the presence of arousals.

分类号： r318-532

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台