文献类型： 会议论文

第一作者： Celina L. Li

作者： Celina L. Li ¹ ; Carl J. Fisher ² ; Runjie Bill Shi ³ ; Brian C. Wilson ¹ ; Jie He ² ; Gang Zheng ¹ ; Robert A. Weersink ⁴ ;

作者机构： 1.Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, CA, M5G1L7 Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON CA, M5G1L7

2.Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON CA, M5G1L7

3.Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON CA, M5G1L7 Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, CA, M5S3G9

4.Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON CA, M5G1L7 Department of Radiation Oncology, University ofToronto, 149 College St, Toronto, ON CA, M5T1P5 Robert.Weersink@rmp.uhn.ca, phone: 416- 274-7518

会议名称： SPIE Conference on Multimodal Biomedical Imaging

主办单位：

页码： 1087115.1-1087115.12

摘要： Diffuse optical tomography in a transrectal configuration (TR-DOT) has been developed to monitor progression of thephotocoagulation front during interstitial photothermal therapy (PTT) of focal prostate cancer. Building on simulationsand feasibility studies in coagulating phantoms, ex vivo porcine muscle and ex vivo canine prostate, the technique wastested here in preclinical canine prostate models in vivo to assess the signal stability and device sensitivity for clinicaltranslation. Co-registration of DOT measurements with magnetic resonance imaging (MRI)-based thermometry inphotocoagulating phantoms provide temperature profiles for correlation with DOT signals changes. DOT measurementswere performed near the treatment fiber tip during PTT with near-infrared light delivery in healthy canine prostate andkidney in vivo. The results were compared with numerical simulations, given the tissue optical absorption and scatteringproperties. In parallel studies, TR-DOT is being investigated to localize prostate tumor and to enhance PTT usingporphyrin-lipid nanoparticles (porphysomes, pPS). The DOT system is being further optimized for real-time monitoringof focal prostate PTT. This work is supported by the Terry Fox Research Institute (grant #1075).

分类号： n-532