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The Effect of Fluid Overload by Saline Infusion on Heart Rate Variability in Men during Sleep

文献类型： 会议论文

第一作者： Daniel Vena MHSc

作者： Daniel Vena MHSc 1 ; Azadeh Yadollahi 1 ;

作者机构： 1.Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada, and Toronto Rehabilitation Institute

关键词： airway;increase;increased

会议名称： Annual International Conference of the IEEE Engineering in Medicine and Biology Society

主办单位：

页码： 2047-2050

摘要： Fluid shift from the legs and into the neck during sleep has been shown to increase tissue pressure around the upper airway and increase sleep apnea severity. Recently, acute fluid overload via saline infusion during sleep was shown to increase sleep apnea severity in an older men (≥40 years of age) but not the younger men (<40 years of age). The purpose of this study was to estimate the changes in the autonomic nervous system response to saline infusion in the younger and older men using well studied time- and frequency domain heart rate variability metrics (HRV). Eighteen healthy men (10 in the younger group and 8 in the older group) slept for up to 3 hours during the day while≈2L of saline was intravenously injected during sleep. An electrocardiogram was collected continuously during the sleep period. Two five minute segments of stage 1 or 2 sleep were selected for analysis of HRV: one before saline infusion and one after completion of saline infusion. Time- and frequency domain metrics of HRV were used to characterize autonomic nervous system response. Results generally showed increased HRV as measured by time-domain statistical measures in the younger men after saline infusion. In the frequency domain, the change in high frequency power from pre- to post-saline infusion was significantly greater in the younger compared to the older men. In addition, there was a borderline significant trend showing an increase in HF power from pre- to post-saline infusion in the younger, but not the older men. These results suggest that only in the younger men and not the older men, parasympathetic nervous activity increased in response to acute fluid overload. This might be one of the mechanisms that increased the severity of OSA in older and not the younger men.

分类号： Q81-53

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