文献类型： 会议论文

第一作者： Jose Zariffa

作者： Jose Zariffa ¹ ; Mary K. Nagai ² ; Zafiris J. Daskalakis ³ ; Milos R. Popovic ¹ ;

作者机构： 1.Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Canada Toronto Rehabilitation Institute, Canada

2.Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada Toronto Rehabilitation Institute, Canada

3.Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry,Faculty of Medicine, University of Toronto, Canada

关键词： bioelectric source localization;multi-contact nerve cuff electrode;rat sciatic nerve;sLORETA;finite-element modeling

会议名称： World congress on medical physics and biomedical engineering

主办单位：

页码： 138-141

摘要： Our goal is to determine the spatial origin of bioelectric activity within a peripheral nerve using recordings from a multi-contact nerve cuff electrode. This task is a bioelectric source localization problem, and a natural question is whether or not algorithms developed for the similar problem of EEG source localization can be applied in the peripheral nerve context. This technique requires a model of the nerve, and the present study aims to determine if using an idealized nerve geometry in the finite-element model is sufficient to achieve acceptable localization performance. Using a leadfield derived from the idealized model, the sLORETA algorithm was applied to recordings from a 56-channel "matrix" nerve cuff electrode placed around the rat sciatic nerve.- The results show that the method was not able to reliably estimate the number and combination of active fascicles. A summary of the issues that need to be addressed before source localization techniques can be applied to peripheral nerves is provided.

分类号： R312