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GUIDING NANOPARTICLE ENHANCED PHOTOTHERMALTHERAPY FOR CANCER WITH PHOTOACOUSTIC THERMAL IMAGING AND DIFFUSE OPTICAL TOMOGRAPHY

文献类型: 会议论文

第一作者: Ivan Kosik

作者: Ivan Kosik 1 ; Sangeet Ghai 2 ; Robert Weersink 3 ; Brian Wilson 4 ;

作者机构: 1.University Health Network Toronto

2.Princess Margaret Cancer Center

3.Institute of Biomaterials and Biomedical Engineering, Radiation Oncology, U of Toronto

4.Medical Biophysics, U of Toronto

关键词: Photothermal therapy;Photoacoustic;Diffuse optical tomography;Thermometry;Nanoparticles

会议名称: Advances in Optics for Biotechnology,Medicine and Surgery Conference

主办单位:

页码: 47-47

摘要: Recent advances in magnetic resonance thermal imaging have begun to enable minimally invasive alternatives to conventional cancer treatment, including Photothermal Therapy (PTT). PTT is a promising technique where thermal tumor destruction is facilitated by NIR laser light delivered through thin optical fibers. As such, this therapeutic method avoids the negative side-effects of surgery, radiation, and chemotherapy, which represent significant hardships for the patient as well as high cost to the health care system. Our ongoing phase II clinical trial of MRI-guided PTT for prostate cancer (PCa) shows promise but suffers from complex, indirect, and slow imaging guidance. This is particularly problematic when treatment is near critical structures like the rectal wall where just a few millimeters of overtreatment may lead to serious injury. Out of abundance of caution the operating surgeon may terminate the treatment prematurely. These drawbacks are contributing to an approximately 30% tumor undertreatment rate in our trial, along with increased risk of recurrence, and are preventing widespread adoption and benefits of PTT.

分类号: r318-53

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