ACCELERATING AND INTENSIFYING MANUFACTURING TO ENABLE LARGE-SCALE SUPPLY OF A NEW ADENOVIRUS-VECTORED VACCINE WITHIN 100 DAYS
文献类型： 会议论文
第一作者： Alexander D Douglas
作者： Alexander D Douglas 1 ; Carina C D Joe 1 ; Rameswara R Segireddy 1 ; Adam Berg 1 ; Yuanyuan Li 1 ; Dimitrios Doultsinos 1 ; Cathy Oliveira 2 ; Asma Ahmad 3 ; Nitin Chopra 4 ; Steffi Scholze 4 ; Piergiuseppe Nestola 4 ; Julia Niemann 4 ;
作者机构： 1.Jenner Institute, University of Oxford
2.Clinical Biomanufacturing Facility, University of Oxford
3.Repligen Corporation
4.Sartorius Stedim Biotech GmbH
关键词： Chimpanzee adenovirus-vectored vaccine;COVID-19 vaccine;Perfusion culture;Emerging pathogens;Alternating tangential flow scaledown models
会议名称： [ "Conference on vaccine technology" , "Vaccine Technology Conference"]
主办单位：
页码： 19-19
摘要： The Coalition for Epidemic Preparedness Innovations' '100-day mission' aspires to launch of a new vaccine within 100 days of pathogen identification. We have previously reported a simple fed batch process and strategy of internationally-distributed manufacturing, which enabled 2 billion doses of the 'Oxford/AstraZeneca' adenovirus-vectored COVID-19 vaccine to be produced in less than 600 days from publication of the SARS-CoV-2 genome sequence. The majority was made and used in low and middle income countries. Here, after briefly reviewing that previous work, we will describe efforts to further improve adenovirus manufacturing for response to future pathogen outbreaks and variants.
分类号： q81-53
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