文献类型： 会议论文

第一作者： GAO Hong-sheng

作者： GAO Hong-sheng ¹ ; ZHANG Shuang-de ¹ ; WANG Shi-xin ¹ ;

作者机构： 1.TianJin Key Laboratory of Occupational and Environmental Hazards Biomarkers, Medical college of Chinese people's Armed Police Force

关键词： Pulmanary fibrosis;Meta analysis;Linear differential model;Regulatory network

会议名称： iCBBE 2009

主办单位：

页码： 3962-3965

摘要： To evaluate cytokine network of pulmonary fibrosis. [Methods] A systematic literature search of EMBASE, MEDLINE, Cochrane Library was conducted through December 2007. Then potential regulatory pathway of cytokines was analyzed with a cubic spline intepolation and a linear differential model. The cytokines of silicosis fibrosis tissue were identified by meta-analysis. [Results] The related cytokines participated pulmonary fibrosis were γ-IFN, IL-10, IL-13, IL-18, IL-4, IL-5, IL-6, IL-8, IGF-1, MCP-1, PDGF, TGF-β1, TNF-α, MMP-2, MMP-9, EGF by meta analysis. The key cytokines of regulated pathway nodes were γ-IFN, IL-10, IL-13, IL-18, IL-6, IGF-1, PDGF, TGF-β1, TNF-α. The cytokines networks of pulmonary fibrosis were composed of the key cytokines, but the other cytokines weren't in the networks due to minor effectiveness induced pulmonary fibrosis or merely inflammatory effectiveness.

分类号： G202-53