文献类型： 会议论文
第一作者： Jian Chen
作者： Jian Chen 1 ; Abdelgawad, M.; Liming Yu; Shakiba, N.; Wei-Yin Chien; Zhe Lu; Geddie, W.B.; Jewett, M.A.S.; Sun, Y.;
作者机构： 1.Inst. of Biomater. & Biomed. Eng., Univ. of Toronto, Toronto, ON, Canada
会议名称： International Conference on Micro Electro Mechanical Systems
主办单位：
页码： 1119-1122
摘要： This paper presents the use of electrodeformation as a method for single cell mechanical characterization. Cells were placed between two microelectrodes with a rectangular AC electric field applied and cell deformation recorded. Numerical simulations were performed to model cell electrodeformation based on the Maxwell stress tensor formulation in which effects of cell electrical property variations on their electrodeformed behaviors were investigated. By comparing the measured morphological changes with those obtained from numerical simulations, we were able to quantify Young's modulus of SiHa cells (601±183 Pa) and ME180 cells (1463±649 Pa), which were then verified using conventional micropipette aspiration (SiHa: 400±290 Pa and ME180: 1070±580 Pa).
分类号： TP271.4`TP271.4
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