文献类型： 会议论文

第一作者： Armando Manduca

作者： Armando Manduca ¹ ; Joel G. Fletcher ² ; Robert J. Wentz ¹ ; Raymond C. Shields ³ ; Terri J. Vrtiska ² ; Hassan Siddiki ² ; Theresa Nielson ² ;

作者机构： 1.Biomathematics Resource, Mayo Clinic College of Medicine 200 1~(st) St. S.W., Rochester, MN, USA 55905

2.Dept. of Diagnostic Radiology, Mayo Clinic College of Medicine 200 1~(st) St. S.W., Rochester, MN, USA 55905

3.Dept. of Cardiovascular Diseases, Mayo Clinic College of Medicine 200 1~(st) St. S.W., Rochester, MN, USA 55905

关键词： Reproducibility;Measurements;CTA

会议名称： SPIE Conference on Medical Imaging 2009

主办单位：

页码： 72620L:1-72620L:8

摘要： Purpose: ECG-gated abdominal CT angiography with reconstruction of multiple, temporally overlapping CT angiography datasets has been proposed for measuring aortic pulsatility. The purpose of this work is to develop algorithms to segment the aorta from surrounding structures from CTA datasets across cardiac phases, calculate registered centerlines and measurements of regional aortic pulsatility in patients with AAA, and to assess the reproducibility of these measurements. Methods: ECG-gated CTA was performed with a temporal resolution of 165 ms, reconstructed to 1 mm slices ranging at 14 cardiac phase points. Data sets were obtained from 17 patients on which two such scans were performed 6 to 12 months apart. Automated segmentation, centerline generation, and registration of centerlines between phases was performed, followed by calculation of cross-sectional areas and regional and local pulsatility. Results: Pulsatility calculations for the supraceliac region were very reproducible between earlier and later scans of the same patient, with average differences less than 1% for pulsatility values ranging from 2% to 13%. Local radial pulsatilities were also reproducible to within -1%. Aneurysm volume changes between scans can also be quantified. Conclusion: Automated segmentation, centerline generation, and registration of temporally resolved CTA datasets permit measurements of regional changes in cross-sectional area over the course of the cardiac cycle (i.e., regional aortic pulsatility). These measurements are reproducible between scans 6-12 months apart, with differences in aortic areas reflecting both aneurysm remodeling and changes in blood pressure. Regional pulsatilities ranged from 2 to 13% but were reproducible at the 1% level.

分类号： N52