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Comparative micro computed tomography study of a vertebral body

文献类型： 会议论文

第一作者： Susanne Drews

作者： Susanne Drews 1 ; Felix Beckmann 2 ; Julia Herzen 2 ; Oliver Brunke 3 ; Phil Salmon 4 ; Sebastian Friess 5 ; Andres Laib 6 ; Bruno Koller 6 ; Thomas Hemberger 3 ; Magdalena Muller-Gerbl 1 ; Bert Muller 7 ;

作者机构： 1.Institute of Anatomy, University of Basel, 4056 Basel, SWITZERLAND

2.GKSS-Research Center, 21502 Geesthacht, GERMANY

3.phoenix|x-ray Systems + Services GmbH, 31515 Wunstorf, GERMANY

4.Skyscan, 2550 Kontich, BELGIUM

5.Gloor Instruments AG, 8610 Uster, SWITZERLAND

6.Scanco Medical AG, 8306 Brutisellen, SWITZERLAND

7.Biomaterials Science Center, University of Basel, 4031 Basel, SWITZERLAND

关键词： spine;bone-cartilage interface;synchrotron radiation;micro computed tomography

会议名称： SPIE Conference on Developments in X-ray Tomography

主办单位：

页码： 70780C:1-70780C:14

摘要： Investigations of bony tissues are often performed using micro computed tomography based on X-rays, since the calcium distribution leads to superior contrast. Osteoporotic bone, for example, can be well compared with healthy one with respect to density and morphology. Degenerative and rheumatoid diseases usually start, however, at the bone-cartilageinterface, which is hardly accessible. The direct influence on the bone itself becomes only visible at later stage. For the development of suitable therapies against degenerative cartilage damages the exact three-dimensional description of the bone-cartilage interface is vital, as demonstrated for transplanted cartilage-cells or bone-cartilage-constructs in animal models. So far, the morphological characterization was restricted to magnetic resonance imaging (MRI) with poor spatial resolution or to time-consuming histological sectioning with appropriate spatial resolution only in two rather arbitrarily chosen directions. Therefore, one should develop μCT to extract the features of low absorbing cartilage. The morphology and the volume of the inter-vertebral cartilage disc of lumbar motion segments have been determined for one PMMA embedded specimen. Tomograms were recorded using nanotom (Phoenix|x-ray, Wunstorf, Germany), μCT 35~( TM) (Scanco Medical, Brutisellen, Switzerland), 1172~(TM) and 1174~(TM) (both Skyscan, Kontich, Belgium), as well as using the SRμCT at HASYLAB/DESY. Conventional and SRμCT can provide the morphology and the volume of cartilage between bones. Increasing the acquisition time, the signal-to-noise ratio becomes better and better but the prominent artifacts in conventional μCT as the result of inhomogeneously distributed bony tissue prevents the exact segmentation of cartilage. SRμCT allows segmenting the cartilage but requires long periods of expensive beamtime to obtain reasonable contrast.

分类号： N52

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