Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A-Induced Spermatogenesis Dysfunction
文献类型： 外文期刊
作者： Fang, Chunyan 1 ; You, Yaodong 1 ; Luo, Fan 2 ; Li, Zheng 3 ; Shen, Yifeng 1 ; Wang, Fangyue 1 ; Zhang, Jingyi 1 ; Gan, Ren-You 4 ; Ye, Yulong 2 ;
作者机构： 1.Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu 610072, Peoples R China
2.Sichuan Acad Agr Sci, Tea Res Inst, Tea Refining & Innovat Key Lab Sichuan Prov, Chengdu 610066, Peoples R China
3.Southwest Univ, Coll Sericulture Text & Biomass Sci, State Key Lab Resource Insects, Minist Agr & Rural Affairs,Key Lab Sericulture Bi, Chongqing 400715, Peoples R China
4.ASTAR, Singapore Inst Food & Biotechnol Innovat SIFBI, 31 Biopolis Way, Singapore 138669, Singapore
5.Natl Univ Singapore, Dept Food Sci & Technol, 2 Sci Dr 2, Singapore 117542, Singapore
关键词： bisphenol A; icariin; nano-drugs; silk fibroin; spermatogenesis dysfunction
期刊名称：ADVANCED HEALTHCARE MATERIALS （ 影响因子：10.0； 五年影响因子：10.6 ）
ISSN： 2192-2640
年卷期： 2023 年
页码：
收录情况： SCI
摘要： Bisphenol A (BPA) is a prevalent endocrine disruptor found in natural environments. Exposure to BPA has been associated with male infertility. The natural phytochemical icariin (ICA) has demonstrated significant promise for the treatment of male infertility. However, its effectiveness is limited due to its low bioavailability, poor water solubility, and insufficient targeting abilities. Herein, novel nanoparticles are generated from the natural silk fibroin, which are used to load ICA. The efficient drug delivery system (ICA-SNPs) result in significantly focused drug distribution to spermatogonium, enhancing the anti-infertility properties of ICA, and can effectively mitigate spermatogenesis dysfunction induced by BPA, control serum sex hormone levels, and enhance testicular ultrastructure. Additionally, the ICA-SNPs restore spermatogenesis dysfunction primarily via the hormone biosynthesis, spermatogonium meiosis process, and glycerophospholipid metabolism. Incorporation of icariin (ICA) into regenerated silk fibroin-based nanoscale drug delivery systems using self-assembly procedures is proposed to develop an efficient drug delivery system (ICA-SNPs) in testicular tissue. The combined analysis of transcriptomics, proteomics, and metabolomics data reveals that ICA-SNPs effectively counteracts the spermatogenesis impairment induced by BPA in mice via the regulation of spermatogonium meiosis process, and glycerophospholipid metabolisms.image
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