文献类型： 外文期刊
作者： Yang, Fayu 1 ; Aliyari, Saba 3 ; Zhu, Zixiang 1 ; Zheng, Haixue 1 ; Cheng, Genhong 3 ; Zhang, Shilei 1 ;
作者机构： 1.Lanzhou Univ, Chinese Acad Agr Sci, Coll Vet Med, Lanzhou Vet Res Inst,State Key Lab Vet Etiol Biol, Lanzhou 730000, Peoples R China
2.Gansu Prov Res Ctr Basic Disciplines Pathogen Biol, Lanzhou 730046, Peoples R China
3.Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90089 USA
期刊名称：TRENDS IN MICROBIOLOGY （ 影响因子：14.9； 五年影响因子：16.9 ）
ISSN： 0966-842X
年卷期： 2025 年 33 卷 6 期
页码：
收录情况： SCI
摘要： Understanding the mechanisms of virus-host interactions is crucial for advancing our knowledge of viral pathogenesis and developing effective antiviral strategies. As novel, highly virulent pathogens continue to emerge, overcoming the challenges in virus-host biology and infection control is more important than ever. The CRISPR-Cas system has revolutionized genetic engineering, offering a precise and efficient application in synthetic biology. It is also invaluable in virology research, diagnostics, and antiviral therapeutics. In this review, we explore the latest advances in CRISPR-Cas-based approaches to elucidate virus-host interactions, focusing on the identification of key receptors and host factors essential for virus infection. Furthermore, we discuss the potential of the CRISPR-Cas system as an antiviral strategy for tackling newly emerging and re-emerging viruses. Finally, we discuss the potential of CRISPR-Cas-based gene editing for the development of innovative viral vaccines.
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