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Immune function in mice enhanced by lamb soup colloidal nanoparticles: Plasma immune, metabolomics, signaling pathways

文献类型： 外文期刊

作者： Fu, Jianing 1 ; Li, Shaobo 2 ; Liu, Ling 1 ; Chen, Li 2 ; Zhang, Dequan 2 ;

作者机构： 1.Shenyang Agr Univ, Coll Food Sci, Dongling St 120, Shenyang 110866, Peoples R China

2.Inst Food Sci & Technol, Chinese Acad Agr Sci, Key Lab Agroprod Qual & Safety Harvest Storage Tra, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China

关键词： Lamb soup; Colloidal nanoparticles; Immune function; Metabolomics; Signaling pathways

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.0； 五年影响因子：8.5 ）

ISSN： 0963-9969

年卷期： 2025 年 209 卷

页码：

收录情况： SCI

摘要： Colloidal nanoparticles (CNPs) are the main form of nutrients in soup products. Lamb soup has the efficacy of improving immunity, benefiting qi and tonifying the kidney. However, its immune mechanism remains unclear. In this study, BALB/c mice were constructed in normal control, prevention (P), model, cyclophosphamide immunodeficiency (CTX) and qi deficiency syndrome (QDS) groups. 18 mice were used for 7-d acclimitization and 5-d intraperitoneal injection modeling. After that, 3 mice were put to death to evaluate the modeling, and 15 mice were used for subsequent detection indicators. The less body weight, shorter exhaustion swimming time, lower organ index and lower plasma immunoglobulin content indicated that the CTX and QDS mouse models were successfully established. Results indicated that CNPs contributed to the weight gain as well as repaired the injury of the spleen and thymus in mice. Plasma immunity indices revealed that CNPs increased the immunoglobulin content of mice in the P, CTX, and QDS groups, thereby improving their immunity. Combined with metabolomics and KEGG database, GnRH, cAMP, Neurotrophin and PI3K-Akt signaling pathways were the key signaling pathways of lamb soup CNPs to enhance mice's immunity. This study aimed to provide a theoretical foundation for lamb soup to enhance immune function.

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