A tailored nanocarrier DMON and CpGs synergistically drive the formulation of a highly immunogenic and long-acting vaccine against echinococcosis
文献类型： 外文期刊
作者： Xin, Ting 1 ; Gao, Xintao 2 ; Tao, Siyi 3 ; Zhou, Chenghao 2 ; Zhang, Zhifang 2 ; Ding, Jiabo 1 ; Ru, Jiaxi 3 ; Li, Yinue 2 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China
2.Chinese Acad Agr Sci, Biotechnol Res Inst, Natl Key Lab Agr Microbiol, Beijing 100081, Peoples R China
3.Wenzhou Med Univ, Inst Adv Res, Cixi Biomed Res Inst, Wenzhou 325035, Zhejiang, Peoples R China
关键词： Nanocarrier; DMON nanoparticle; CpG adjuvants; Vaccine; Echinococcosis; Early; robust and long-lasting immunity
期刊名称：MATERIALS TODAY BIO （ 影响因子：10.2； 五年影响因子：10.2 ）
ISSN： 2590-0064
年卷期： 2025 年 32 卷
页码：
收录情况： SCI
摘要： Hydatid disease (echinococcosis) is a zoonotic parasitic disease that seriously endangers human health and livestock production. To develop a safer, more effective vaccine with an exceptionally long-lasting immune response, we employed an 'all-in-one' strategy to construct a nanovaccine against echinococcosis. In this system, a dendritic mesoporous organosilica nanoparticle (DMON), Eg95 antigen, and two types of CpG potentiators (CpG ODN and pCpG) were integrated into a single nanoplatform. Compared to the commercial Quil-Aformulated vaccine, these two nanovaccines exhibited significant advantages in inducing early, robust, and long-lasting protective immune responses, especially in terms of IgG1 antibody responses and Th1 cytokine TNF alpha secretion. Notably, the certain adjuvant combination (DMON + pCpG) formulated-vaccine Eg95N + pCpG@DMON conferred stronger adjuvanticity to the antigen than Quil-A during the late stage (42-84 days). Systematic evaluation demonstrated excellent biodegradability and biosafety of DMON and its-based vaccine. This research provides a strong foundation for upgrading vaccines against echinococcosis.
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