文献类型： 外文期刊
作者： Pan, Siyu 1 ; He, Haijuan 2 ; An, Tong-Qing 1 ; Wang, Shujie 1 ;
作者机构： 1.Chinese Acad Agr Sci, Harbin Vet Res Inst, Natl Key Lab Vet Biotechnol, Harbin 150001, Peoples R China
2.Heilongjiang Acad Agr Sci, Inst Anim Husb, Harbin 150086, Peoples R China
3.Heilongjiang Prov Key Lab Vet Immunol, Harbin 150069, Peoples R China
关键词：
期刊名称：MICROORGANISMS （ 影响因子：4.2； 五年影响因子：4.6 ）
ISSN：
年卷期： 2025 年 13 卷 7 期
页码：
收录情况： SCI
摘要： Streptococcus suis (S. suis) is a major pathogen in pigs and an emerging zoonotic agent which causes serious infections in humans. It is also an immunosuppressive pathogen that exerts detrimental effects on the thymus, spleen, lymph nodes, and macrophages, impairing their ability to perform their normal physiological functions. S. suis induces thymic atrophy, splenomegaly, and lymphadenectasis and triggers apoptosis in T cells and B cells, as well as pyroptosis in macrophages within immune organs. Subsequently, T cell subsets in peripheral blood become abnormal, and the expression of cytokines becomes dysregulated, which leads to host immunosuppression, suggesting a new virulence mechanism of S. suis.
- 相关文献
作者其他论文 更多>>
-
Anti-Tumor Effects of Sheep Umbilical Cord Mesenchymal Stem Cells on Melanoma Cells
作者：Yue, Fengjiao;Zhao, Yuqing;Lv, Yiting;Li, Songmei;Wang, Weihai;Li, Yajun;Wang, Chunsheng;Wang, Shujie
关键词：mesenchymal stem cells; melanoma; RNA-seq; nude mouse; subcutaneous tumor
-
The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2
作者：Bai, Yuan-Zhe;Wang, Shujie;Sun, Yue;Liu, Yong-Gang;Zhang, Hong-Liang;Wang, Qian;Huang, Rui;Rao, Cui-Hong;Xu, Shi-Jia;Tian, Zhi-Jun;An, Tong-Qing;Cai, Xue-Hui;Tang, Yan-Dong;Cai, Xue-Hui;Tang, Yan-Dong;Tang, Yan-Dong
关键词：arterivirus; PRRSV; nsp2; assembly; glycoprotein (GP); nucleocapsid (N) protein
-
Heterocycle-based dynamic covalent chemistry for dynamic functional materials
作者：Ma, Zeyu;Pan, Siyu;Zeng, Yuan;Wei, Yen;Tao, Lei;Yang, Yang;Wang, Bo
关键词：
-
Epitope Mapping of Senecavirus A 3A Protein Using Monoclonal Antibodies
作者：Meng, Liang;Tian, Xiao-Xiao;Xiang, Xu-Yan;Qi, Xin-Yu;Zhou, Han-Rong;Xiao, Pei-Yu;An, Tong-Qing;Meng, Fan-Dan;Wang, Hai-Wei;An, Tong-Qing
关键词：3A protein; epitope; monoclonal antibody;
Senecavirus A -
GP2a I118 and GP4 D43 play critical roles in the attachment of PRRSV to the CD163 receptor: implications for anti-PRRSV infection targets
作者：Liu, Guoqing;Huang, Xinyi;Yang, Yongbo;Chen, Meng;Tian, Xiaoxiao;Song, Hao;Wang, Haojie;Wang, Shujie;Wang, Haiwei;Cai, Xuehui;An, Tongqing;Huang, Xinyi;An, Tongqing;Yang, Yongbo;Cai, Xuehui
关键词：PRRSV; cellular tropism; CD163 receptor; blocking peptide
-
Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine
作者：Bai, Yuan-Zhe;Xu, Hu;Liu, Yong-Gang;Sun, Yue;Xu, Shi-Jia;Wang, Meng-Xin;Wang, Qian;Tian, Zhi-Jun;An, Tong-Qing;Cai, Xue-Hui;Zhang, Hong-Liang;Tang, Yan-Dong;Leng, Chao-Liang;Wang, Gang;Cai, Xue-Hui;Tang, Yan-Dong;Tang, Yan-Dong
关键词：PRRSV; nsp2; live attenuated vaccine; uncoating; primary PAMs
-
Development of blocking ELISA for detection anti-PRRSV antibodies and serological investigation of PRRSV in China
作者：Wang, Shujie;Chen, Tianfeng;Yang, Yong-Bo;Wang, Hongfeng;Sun, Mingxia;Gao, Kexin;Wei, Ziyi;Bai, Yuanzhe;Tang, Yan-Dong;Cai, Xuehui;An, Tongqing;Wang, Shujie;An, Tongqing;Cai, Xuehui
关键词：Porcine reproductive and respiratory syndrome; virus; Nucleocapsid (N) protein; Monoclonal antibodies; b-ELISA
