Dauriporphine inhibited lung cancer cell viability, motility, and energy metabolism through the miR-424-5p/MAPK14 axis
文献类型： 外文期刊
作者： Du, Yan-Jia 1 ; Lv, Jin-Peng 3 ; Fu, Yao 1 ; Lan, Meng 1 ; Li, Jing-Feng 4 ; Zhang, Hui 1 ; Wu, Nan 1 ;
作者机构： 1.Changchun Humanities & Sci Coll, Dept Chinese Med & Hlth Care, 1488 Boshuo Rd,Jingyue Natl Hitech Ind Dev Zone, Changchun 130117, Jilin, Peoples R China
2.Jilin Northeast Asia Biotechnol Dev Co Ltd, Room 16-3-105,Luwafangfuao I,Jingyue Dev Zone, Changchun 130033, Jilin, Peoples R China
3.Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130022, Peoples R China
4.Changchun Univ Chinese Med, Coll Pharm, Changchun 130117, Peoples R China
关键词： Anti-lung cancer treatment; Dauriporphine; Cell viability; Cell motility; Energy metabolism
期刊名称：HEREDITAS （ 影响因子：2.5； 五年影响因子：2.6 ）
ISSN： 1601-5223
年卷期： 2025 年 162 卷 1 期
页码：
收录情况： SCI
摘要： BackgroundDauriporphine is a major ingredient of Manispernum daericum DC., which has been demonstrated to show wide anti-tumor activities. miR-424-5p, as a regulator of lung cancer, was hypothesized to serve as the therapeutic target for dauriporphine This study evaluated the potential of dauriporphine in treating lung adenocarcinoma and revealed the underlying molecular mechanism.ResultsThe anti-tumor effect of dauriporphine on lung adenocarcinoma was assessed in A549 cells, and it was found that dauriporphine significantly inhibited the viability of A549 cells in a concentration-dependent manner with the half maximal inhibitory concentration (IC50) value of 10.57 mu M. Dauriporphine induced decreasing cell growth, motility, and energy metabolism, indicating the anti-tumor effect of dauriporphine on A549 cells. Dauriporphine inducing elevated miR-424-5p levels, while silencing miR-424-5p significantly recovered cell viability, migration, and energy metabolism of A549 cells. Mitogen-activated protein Kinase 14 (MAPK14) was negatively regulated by miR-424-5p, and the knockdown of MAPK14 could reverse the protective effect of miR-424-5p on dauriporphine-treated A549 cells.ConclusionDauriporphine inhibited cell growth, metastasis, and glycolysis-related energy metabolism of lung adenocarcinoma cells via modulating miR-424-5p/MAPK14 axis. Dauriporphine can be considered in drug development for lung adenocarcinoma.Clinical trial numberNot applicable.
- 相关文献
作者其他论文 更多>>
-
Metatranscriptomic insights into the mechanism of 'Multiple Qu' utilization in Jian-flavor Baijiu fermentation
作者：Xu, Shanshan;Hu, Weiqi;Zhou, Hao;Xu, Boyang;Wang, Ruijuan;Liu, Wuyang;Liu, Yong-xin;Li, Xingjiang;Liu, Yong-xin;Xu, Qinxiang;Zhang, Hui
关键词：Jian-flavor Baijiu; Multiple-qu fermentation; Single-qu fermentation; Metatranscriptomic analysis; Microbiota
-
Effect of salt-induced supercooling stability on the quality of chicken breast during supercooled storage
作者：Yang, Yiping;Li, Hongliang;Huang, Junrong;Yang, Yiping;Lin, Hengxun;Chen, Yong;Cui, Liye;Xia, Shuangmei;Zhang, Chunhui;Li, Xia;Zhang, Hui;He, Jiansheng;Sun, Xuemei
关键词：Meat preservation; Salt; Supercooling stability; Freezing damage; Quality assessment
-
Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18
作者：Li, Kunyu;Song, Yize;Fan, Yekai;Zhang, Hui;Chu, Mingxing;Liu, Yufang
关键词：Goat; miRNA-seq; Skeletal myoblast proliferation; chi-miR-103-3p;
FGF18 -
Predicting the environmental fate of biodegradable mulch films: A machine learning approach for sustainable agriculture
作者：Chen, Shan;Xu, Guohailin;Chen, Jingwen;Jiang, Xizhi;Liu, Ziwen;Lin, Zhiwei;Xu, Lei;Xu, Guohailin;Zhang, Hui;Zhang, Congzhi;Zhang, Jiabao
关键词：Machine learning; Biodegradable plastic mulch film; Meta-analysis; Prediction model; Plastic pollution
-
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function
作者：Gong, Pan;Gao, Mengxin;Chen, Yalin;Zhang, Mingzhen;Hu, Xiaohua;Zhao, Siwen;Pan, Mengjiao;Cao, Buwei;Zhou, Xueping;Li, Fangfang;Gao, Mengxin;Zhou, Xueping;Huang, Yucong;Shen, Qingtang;Zhang, Hui;Liu, Yong;Liu, Yong;Lozano-Duran, Rosa;Wang, Aiming
关键词：positive-sense single-stranded RNA viruses; tobamoviruses; cucumber green mottle mosaic virus; small ORFs; peroxisomes; virus pathogenicity
-
An efficient target-mutant screening platform of model variety Ci846 facilitates genetic studies of Setaria
作者：Zhang, Hui;Liang, Hongkai;Zhi, Hui;Yuan, Di;Yao, Qi;Zhang, Renliang;Xing, Lihe;Yang, Baolan;Sang, Luman;Zhao, Lirong;Tang, Sha;Wang, Liwei;Wang, Hailong;Ren, Yushuang;Zhang, Hui;Zhang, Yanyan;Wang, Enbo;Man, Xinyu;Xu, Gongjin;Zhang, Linlin;He, Qiang;Diao, Xianmin;Jia, Guanqing;Diao, Xianmin;Jia, Guanqing
关键词：Setaria; foxtail millet; mutant library; phenotypic characterization; wholegenome resequencing
-
Centromere-size reduction and chromatin state dynamics following intergenomic hybridization in cotton
作者：Han, Jinlei;Dai, Yan;Zhang, Xin;Tian, Jingjing;Zhou, Jialiang;Xu, Xinqi;Chen, Qi;Kou, Xiaobing;Xu, Lei;Wu, Xinyu;Sun, Ziying;Geng, Jiahui;Li, Lin;Qiu, Chenyu;Mehari, Teame Gereziher;Wang, Baohua;Zhang, Hui;Wang, Kai;Hu, Guanjing;Wendel, Jonathan F.;Hu, Guanjing;Shen, Xinlian;Xu, Zhenzhen
关键词：
