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Analysis of the stereoselective fate and toxicity of penflufen in the water-sediment system for risk reduction

文献类型： 外文期刊

作者： Liu, Tong 1 ; Yan, Saihong 2 ; Sun, Wei 1 ; You, Xiangwei 1 ; Zheng, Lei 3 ; Wang, Xiuguo 1 ;

作者机构： 1.Chinese Acad Agr Sci CAAS, Tobacco Res Inst, Qingdao 266101, Peoples R China

2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China

3.Natl Res Ctr Environm Anal & Measurement, Sino Japan Friendship Ctr Environm Protect, State Environm Protect Key Lab Dioxin Pollut, Beijing 100029, Peoples R China

关键词： Chiral pesticide; SDHIs fungicide; Microcosmic model; Multi-omics Sequencing; AlphaFold2

期刊名称：ENVIRONMENT INTERNATIONAL （ 影响因子：9.7； 五年影响因子：11.6 ）

ISSN： 0160-4120

年卷期： 2024 年 194 卷

页码：

收录情况： SCI

摘要： Chiral succinate dehydrogenase inhibitor (SDHI) fungicides are widely used in agricultural production, but there is insufficient research on their environmental risk in water-sediment ecosystems. Here, the stereoselective fate and toxic effects of the chiral SDHI fungicide, penflufen, in the water-sediment system were investigated. The results showed that S-penflufen is more persistent in water, sediment, and zebrafish. Additionally, the sorption coefficient (Koc) in sediment and uptake rate constant (Ku) in zebrafish of S-penflufen were higher than those of R-penflufen. The acute toxicity of S-penflufen to zebrafish, Daphnia magna and Chironomus kiiensis were 32-, 6.1-, and 8.9-fold higher than those of R-penflufen. The AlphaFold2 and molecular docking results showed that Spenflufen had stronger binding capability with SDH in the three water-sediment organisms than R-penflufen. Therefore, S-penflufen induced stronger sub-chronic toxic effects on zebrafish than R-penflufen, even at 0.05 mg/ L. The results of multi-omics analysis showed that S-penflufen affected the tricarboxylic acid cycle in zebrafish and induced antioxidant, detoxification, and immune system responses, ultimately affecting zebrafish metabolic processes and cellular function. The overall results indicate that S-penflufen has a higher risk in water-sediment systems. Moreover, combining multi-omics and AlphaFold2 techniques facilitates the elucidation of the molecular mechanism of the stereoselective toxic effects of chiral pesticides.

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