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Beyond pathways: Accelerated flavonoids candidate identification and novel exploration of enzymatic properties using combined mapping populations of wheat

文献类型： 外文期刊

作者： Chen, Jie 1 ; Zhang, Yueqi 1 ; Wei, Jiaqi 1 ; Hu, Xin 1 ; Yin, Huanran 1 ; Liu, Wei 1 ; Li, Dongqin 1 ; Tian, Wenfei 6 ; Hao, Yuanfeng 6 ; He, Zhonghu 6 ; Fernie, Alisdair R. 7 ; Chen, Wei 1 ;

作者机构： 1.Huazhong Agr Univ, Natl Key Lab Crop Genet Improvement, Wuhan, Peoples R China

2.Huazhong Agr Univ, Natl Ctr Plant Gene Res Wuhan, Wuhan, Peoples R China

3.Hubei Hongshan Lab, Wuhan, Peoples R China

4.Yazhouwan Natl Lab, Sanya, Peoples R China

5.Wuhan Acad Agr Sci, Wuhan, Peoples R China

6.Chinese Acad Agr Sci, Inst Crop Sci, Natl Wheat Improvement Ctr, Beijing, Peoples R China

7.Max Planck Inst Mol Plant Physiol, Potsdam Golm, Germany

关键词： mGWAS; mQTL; flavonoid pathway; wheat; enzymatic engineering

期刊名称：PLANT BIOTECHNOLOGY JOURNAL （ 影响因子：13.8； 五年影响因子：13.2 ）

ISSN： 1467-7644

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Although forward-genetics-metabolomics methods such as mGWAS and mQTL have proven effective in providing myriad loci affecting metabolite contents, they are somehow constrained by their respective constitutional flaws such as the hidden population structure for GWAS and insufficient recombinant rate for QTL. Here, the combination of mGWAS and mQTL was performed, conveying an improved statistical power to investigate the flavonoid pathways in common wheat. A total of 941 and 289 loci were, respectively, generated from mGWAS and mQTL, within which 13 of them were co-mapped using both approaches. Subsequently, the mGWAS or mQTL outputs alone and their combination were, respectively, utilized to delineate the metabolic routes. Using this approach, we identified two MYB transcription factor encoding genes and five structural genes, and the flavonoid pathway in wheat was accordingly updated. Moreover, we have discovered some rare-activity-exhibiting flavonoid glycosyl- and methyl-transferases, which may possess unique biological significance, and harnessing these novel catalytic capabilities provides potentially new breeding directions. Collectively, we propose our survey illustrates that the forward-genetics-metabolomics approaches including multiple populations with high density markers could be more frequently applied for delineating metabolic pathways in common wheat, which will ultimately contribute to metabolomics-assisted wheat crop improvement.

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