文献类型： 外文期刊
作者： Li, Haopeng 1 ; Qian, Xuliang 3 ; Mohanram, Harini 4 ; Han, Xiao 1 ; Qi, Huitang 2 ; Zou, Guijin 3 ; Yuan, Fenghou 2 ; Miserez, Ali 1 ; Liu, Tian 2 ; Yang, Qing 7 ; Gao, Huajian 3 ; Yu, Jing 1 ;
作者机构： 1.Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore, Singapore
2.Dalian Univ Technol, Sch Bioengn, MOE Key Lab Biointelligent Mfg, Dalian, Peoples R China
3.Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore, Singapore
4.Nanyang Technol Univ, Sch Biol Sci, Div Struct & Computat Biol, Singapore, Singapore
5.ASTAR, Inst High Performance Comp, Singapore, Singapore
6.Nanyang Technol Univ, Ctr Sustainable Mat SusMat, Sch Mat Sci & Engn, Biol & Biomimet Mat Lab BBML, Singapore, Singapore
7.Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China
8.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Genome Anal Lab,Minist Agr & Rural Affairs, Shenzhen, Peoples R China
9.Tsinghua Univ, Dept Engn Mech, Appl Mech Lab, Mechano X Inst, Beijing, Peoples R China
10.Nanyang Technol Univ, Inst Digital Mol Analyt & Sci, Singapore, Singapore
期刊名称：NATURE NANOTECHNOLOGY （ 影响因子：38.3； 五年影响因子：39.9 ）
ISSN： 1748-3387
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Biological systems can create materials with intricate structures and specialized functions. In comparison, precise control of structures in human-made materials has been challenging. Here we report on insect cuticle peptides that spontaneously form nanocapsules through a single-step solvent exchange process, where the concentration gradient resulting from the mixing of water and acetone drives the localization and self-assembly of the peptides into hollow nanocapsules. The underlying driving force is found to be the intrinsic affinity of the peptides for a particular solvent concentration, while the diffusion of water and acetone creates a gradient interface that triggers peptide localization and self-assembly. This gradient-mediated self-assembly offers a transformative pathway towards simple generation of drug delivery systems based on peptide nanocapsules. Biobased materials are of interest for many applications. Here the authors report insect-derived peptides that self-assemble into hollow nanocapsules through a gradient-driven, single-step, solvent exchange process, enabling the encapsulation of diverse cargoes with potential for drug delivery applications.
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