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Research advances in replication-deficient viral vector vaccines

文献类型： 外文期刊

作者： Wang, Junna 1 ; Cui, Jin 3 ; Li, Guoxin 1 ; Yu, Lingxue 1 ;

作者机构： 1.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai, Peoples R China

2.Shanghai Key Lab Vet Biotechnol, Shanghai, Peoples R China

3.Northeast Agr Univ, Coll Vet Med, Harbin, Heilongjiang, Peoples R China

关键词： replication-deficient virus; replication-deficient vaccine; single-cycle replication; safety; vector; vaccine

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：2.9； 五年影响因子：3.3 ）

ISSN：

年卷期： 2025 年 12 卷

页码：

收录情况： SCI

摘要： In recent years, replication-deficient viral vector vaccines have attracted much attention in the field of vaccine research and development due to their high safety and immunogenicity. These vaccines use genetic modifications to engineer viral vectors that make them unable to replicate but effective in expressing recombinant proteins and induce immune responses. Currently, replication-deficient adenovirus vectors and poxvirus vectors are widely used in vaccine R&D for a variety of infectious diseases in humans and animals, including AIDS, hepatitis B, pseudorabies, avian influenza, infectious bronchitis in poultry, and foot-and-mouth disease. Replication-deficient viral vaccines have been shown to effectively induce neutralizing antibodies and cellular immune responses, thereby providing effective immune protection. Future development of genetic engineering technology and continuous in-depth research on viral vectors should lead to replication-deficient viral vector platforms that have an essential role in preventing and controlling existing and emerging infectious diseases.

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