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Engineering plant hosts for high-efficiency accumulation of flavonoids: Advances, challenges and perspectives

文献类型： 外文期刊

作者： Xu, Yameng 1 ; Ge, Xiaoyang 1 ; Lv, Yongkun 2 ; Yang, Zhaoen 1 ; Li, Fuguang 1 ; Yang, Zuoren 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Cotton Res, State Key Lab Cotton Biobreeding & Integrated Util, Anyang 455000, Henan, Peoples R China

2.CAAS, Inst Western Agr, Xinjiang Key Lab Crop Gene Editing & Germplasm Inn, Changji 831100, Xinjiang, Peoples R China

3.Zhengzhou Univ, Sch Agr Sci, State Key Lab Cotton Biobreeding & Integrated Util, Zhengzhou Res Base, Zhengzhou 450001, Henan, Peoples R China

关键词： Flavonoid; Plant host; Transcription factor; Metabolic engineering; Synthetic biology

期刊名称：BIOTECHNOLOGY ADVANCES （ 影响因子：12.5； 五年影响因子：15.7 ）

ISSN： 0734-9750

年卷期： 2025 年 84 卷

页码：

收录情况： SCI

摘要： Flavonoids are a vital class of compounds that contribute to plant resistance and also beneficial to human health. Increasing plant flavonoid content or enabling the synthesis of specific flavonoids can enhance plant resistance to biotic and abiotic stress while augmenting their nutritional value, thereby supporting sustainable agricultural practices. Although numerous studies have focused on increasing flavonoid content in plants, traditional engineering strategies lack the precision required to selectively regulate the synthesis of individual flavonoids. In contrast, systems and synthetic biology provide innovation approaches to address these challenges. Here, we summarize research on the distribution, biosynthetic pathways, and transcriptional regulation of flavonoids in plants. Subsequently, we analyze current progress in altering plant-flavonoid content, including transcriptional regulation, transporter engineering, and lifting rate-limiting steps. Additionally, we summarize potential strategies for precisely altering flavonoid biosynthetic pathways, including the selection of ideal hosts, designating artificially modifiable genetic elements, accelerating enzyme evolution by protein engineering, enhancing cascade biocatalysis and metabolic flux, and rebalancing metabolic fluxes. Finally, we discuss current limitations and prospects for building a next-generation plant hosts for high-efficiency flavonoid biosynthesis. This review aims to provide theoretical guidance for the modification and reconstruction of flavonoid biosynthesis in plants using systems and synthetic biology approaches.

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