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Proteomics reveals the hemolymph components of partially fed Hyalomma asiaticum ticks

文献类型： 外文期刊

作者： Yuan, Chuanfei 1 ; Yang, Qingtai 3 ; Wu, Jia 4 ; Peng, Yun 4 ; Li, Yufeng 2 ; Xiong, Shirui 1 ; Zhou, Jinlin 5 ; Wang, Manli 2 ; Hu, Zhihong 2 ; Zou, Zhen 3 ; Xia, Qianfeng 1 ;

作者机构： 1.Hainan Med Univ, Affiliated Hosp 2, Sch Trop Med, Key Lab Trop Translat Med Minist Educ,NHC Key Lab, Haikou 571199, Hainan, Peoples R China

2.Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430071, Peoples R China

3.Inst Zool, Chinese Acad Sci, State Key Lab Integrated Management Pest Insects &, Beijing 100101, Peoples R China

4.Chinese Acad Sci, Mega Sci Ctr Biosafety Res, Wuhan Natl Biosafety Lab, Wuhan 430071, Peoples R China

5.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Key Lab Anim Parasitol Minist Agr, Shanghai 200241, Peoples R China

关键词： Hemolymph; Ticks; Proteomics; Immunity; Coagulation

期刊名称：TICKS AND TICK-BORNE DISEASES （ 影响因子：3.817； 五年影响因子：3.986 ）

ISSN： 1877-959X

年卷期： 2022 年 13 卷 6 期

页码：

收录情况： SCI

摘要： Hemolymph infection facilitates pathogen invasion of internal tick tissues. However, the overall protein composition of the hemolymph has not been analyzed for any tick species. Here, a gel based liquid chroma-tography tandem mass spectrometry method was used to characterize the hemolymph proteome of Hyalomma asiaticum females during blood feeding. A total of 311 proteins were identified. Hemelipoglyco-carrier proteins, apolipophorin-like proteins, and intracellular proteins were the most abundant proteins. Thirteen immunity -related proteins were identified, including peptidoglycan recognition protein (PGRP), Thioester-containing proteins (TEPs), clip-serine proteinases, serpins and Dome. The presence of hemocytin, proclotting enzyme homologs, serpins, TEPs, factor D-like protein and the lack of coagulin, hemocyanin, and prophenoloxidase suggest ticks may possess a unique coagulation system, which is largely different from that of insects. Taken together, the study revealed the constitution, level, and possible functions of global hemolymph proteins in H. asiaticum and could facilitate the discovery of new targets for control of tick-borne pathogens.

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