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Multifunctional Dual Network Hydrogel Loaded with Novel Tea Polyphenol Magnesium Nanoparticles Accelerates Wound Repair of MRSA Infected Diabetes

文献类型： 外文期刊

作者： Hu, Xulin 1 ; He, Jian 5 ; Qiao, Liang 6 ; Wang, Chun 3 ; Wang, Yao 3 ; Yu, Rongxin 8 ; Xu, Wei 8 ; Wang, Fan 9 ; Yang, Shuhao 10 ; Zhang, Xiangchun 8 ; Qian, Zhiyong 1 ;

作者机构： 1.Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Sichuan, Peoples R China

2.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

3.Chengdu Univ, Clin Med Coll, Chengdu 610081, Sichuan, Peoples R China

4.Chengdu Univ, Affiliated Hosp, Chengdu 610081, Sichuan, Peoples R China

5.Henan Univ Sci & Technol, Coll Med, Luoyang 471023, Peoples R China

6.Henan Univ Sci & Technol, Affiliated Hosp 1, Coll Clin Med, Key Lab Neuromol Biol, Luoyang 471003, Peoples R China

7.Chengdu Univ, Affiliated Hosp, Chengdu 610081, Peoples R China

8.Chinese Acad Agr Sci, Tea Res Inst, Hangzhou 310008, Peoples R China

9.Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu 610041, Sichuan, Peoples R China

10.Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing 400016, Peoples R China

关键词： diabetes wound healing; double network hydrogel; magnesium nanoparticles; MRSA biofilm; tea polyphenol

期刊名称：ADVANCED FUNCTIONAL MATERIALS （ 影响因子：19.0； 五年影响因子：19.2 ）

ISSN： 1616-301X

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection, caused by impaired glucose metabolism in diabetic foot patients, poses a significant obstacle to the healing process and carries a high risk of being life-threatening. Due to microvascular occlusion and the entrenchment of MRSA biofilms in diabetic foot, controlling and effectively treating MRSA infection remains challenging. Traditional hydrogels suffer from swelling-related mechanical issues and inadequate drug release control, limiting their applications as biomimetic extracellular matrices for wound healing. Herein, a double-network hydrogel composed of polyvinyl alcohol, sodium alginate, and gelatin (PSG) loaded with tea polyphenol self-assembled magnesium nanoparticles (TP-Mg NPs) with antibacterial and angiogenic properties for treating MRSA-infected diabetic foot wounds under hyperglycemic conditions is constructed. TP-Mg@PSG exhibits enhanced mechanical strength and toughness for wound attachment and recovery movement torsion. In the acidic infection microenvironment representative of MRSA-infected wounds, the TP-Mg@PSG hydrogel degrades to release TP-Mg NPs, showing excellent anti-MRSA biofilm effect and high biocompatibility. Such localized controlled release enhances the inhibition of MRSA infection and reduces the inflammatory response in rats, promoting cell proliferation and rapid wound repair. Therefore, this study presents a multifunctional biomaterial system for managing diabetic foot conditions, highlighting its potential for clinical applications.

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