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Establishment of an animal model for monkeypox virus infection in dormice

文献类型： 外文期刊

作者： Song, Gaojie 1 ; Cheng, Lingling 1 ; Liu, Jun 1 ; Zhou, Yu 3 ; Zhang, Cuiling 2 ; Zong, Yuping 4 ;

作者机构： 1.Jiujiang Univ, Sch Basic Med Sci, Jiangxi Prov Key Lab Cell Precis Therapy, Jiujiang 332005, Jiangxi, Peoples R China

2.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130122, Peoples R China

3.Navy 971 Hosp, Dept Dis Prevent & Control, Qingdao, Peoples R China

4.964 Hosp Joint Logist Support Force, Cadre Ward, Changchun 130122, Peoples R China

关键词： Dormice; MPXV; Animal model; Pathological changes

期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.9； 五年影响因子：4.3 ）

ISSN： 2045-2322

年卷期： 2025 年 15 卷 1 期

页码：

收录情况： SCI

摘要： This study aims to establish an animal model of monkeypox virus (MPXV) infection in dormice through intranasal inoculation. Male dormice aged 4-5 months were selected as experimental subjects and administered different titers of MPXV (103.5 PFU, 104.5 PFU, and 105.5 PFU, respectively) via nasal instillation. Within 14 days post-infection, clinical indicators such as survival rate, body weight changes, respiratory status, and mental state were continuously monitored. Additionally, tissue samples from the lungs, liver, spleen, and trachea of dormice from each group were collected on the 5th and 10th days for virus titer detection, and histopathological analysis was performed on lung samples collected on the 5th and 10th days. Dormice infected with MPXV exhibited typical symptoms such as appetite loss, continuous body weight reduction, aggravated respiratory difficulties, accompanied by lethargy, chills, and other clinical manifestations similar to human monkeypox infection. Virological tests further confirmed the distribution of MPXV in multiple vital organs of dormice, including the lungs, liver, spleen, and trachea, with particularly significant pathological damage observed in lung tissue. An MPXV infection model in dormice was successfully established through intranasal inoculation with a titer of 105.5 PFU MPXV, which can be used for studying the infection mechanism and pharmacology of MPXV.

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