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Mycoplasma Biofilms: Characteristics and Control Strategies

文献类型： 外文期刊

作者： Liang, Jingyi 1 ; Deng, Baoyi 1 ; Li, Weihuo 1 ; Qi, Jingjing 2 ; Li, Yangshuo 1 ; Wang, Xueyan 1 ; Li, Ming 1 ; Yang, Hong 1 ; Zhang, Nan 1 ;

作者机构： 1.Foshan Univ, Sch Anim Sci & Technol, Foshan 528225, Peoples R China

2.Chinese Acad Agr Sci CAAS, Shanghai Vet Res Inst, 518 Ziyue Rd, Shanghai 200241, Peoples R China

关键词： Mycoplasma; biofilm; drug resistance; virulence

期刊名称：MICROORGANISMS （ 影响因子：4.2； 五年影响因子：4.6 ）

ISSN：

年卷期： 2025 年 13 卷 8 期

页码：

收录情况： SCI

摘要： The Mycoplasmataceae are a family of bacteria that typically cause respiratory, arthritic, and genitourinary disease in humans. Mycoplasma spp. of animal origin are also the causative agents of porcine wheezing disease, chronic respiratory disease and arthritis in chickens and other conditions. These diseases have a significant impact on public health and the economic development of livestock breeding. Clinical prevention and treatment of mycoplasma infections is primarily dependent on the use of antibiotics. However, inappropriate and excessive use of antimicrobials has enabled resistance development that has become a significant clinical concern. Mycoplasma are also robust biofilm producers, and this process is a major factor for the persistence of these infections, especially in conjunction with common antibiotic resistance mechanisms, including target gene mutations and the action of efflux pumps. A mycoplasma biofilm refers to a structured and stable microbial community formed by Mycoplasma spp. adhering to biological or non-biological surfaces under suitable conditions and secreting extracellular polymers (EPS) such as polysaccharides. This process allows the microorganisms to adapt to their surrounding environment and survive during the growth process. These biofilms render bacteria more resistant to antimicrobials than planktonic bacteria, resulting in biofilm-associated infections that are more challenging to eradicate and more likely to recur. The current study reviews progress from the fields of biofilm formation, structure and identification, correlations between biofilms and drug resistance and virulence as well as methods of biofilm prevention and control. Our aim was to provide a reference basis for the subsequent in-depth understanding of the research of mycoplasma biofilms.

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