Genome scanning reveals novel candidate genes for vertebral and teat number in the Beijing Black Pig
文献类型： 外文期刊
作者： Niu, N. 1 ; Wang, H. 2 ; Shi, G. 2 ; Liu, X. 2 ; Liu, H. 2 ; Liu, Q. 1 ; Yang, M. 1 ; Wang, L. 1 ; Zhang, L. 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Key Lab Anim Poultry Genet Breeding & Reprod, Dept Anim Genet & Breeding,Minist Agr, Beijing 100193, Peoples R China
2.Beijing Heiliu Stockbreeding Technol Co Ltd, Beijing 102211, Peoples R China
关键词： ABCD4; genome-wide association study; HOX; NTRK2
期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）
ISSN： 0268-9146
年卷期： 2021 年 52 卷 5 期
页码：
收录情况： SCI
摘要： Porcine vertebral and teat numbers are variable and important economic traits in pig production. However, the quantitative trait loci (QTL) and candidate genes for both of these traits in the Beijing Black Pig are not yet known. In the present study, number of vertebrae and number of teats were obtained for 891 individuals of the Beijing Black Pig and genotyped using the Illumina Porcine 50 K BeadChip. Genome scanning was performed to detect associated variants and candidate genes for both traits using a genome-wide association study by TASSEL software. For vertebral number, 15 significant SNPs were located on SSC7. According to linkage disequilibrium analysis on SSC7, a haplotype block of 221 kb from 97.4 to 97.6 Mb was shown to contain a good candidate gene ABCD4. Interestingly, on SSC12, we recorded a novel QTL containing three significant SNPs and 34 annotated genes from 24.0 to 25.7 Mb for vertebral number. Of the 34 genes, nine Hox family genes (HOXB 1-7, 9, and 13) were found to be good candidate genes. Using the 34 genes, a gene ontology analysis was performed to detect enrichment of anterior/posterior pattern specification. For teat number, a novel chromosome-wide significant QTL was identified on SSC10. In this QTL region, one significant SNP was identified. The nearest gene, NTRK2, was regarded as a candidate gene. The present results expanded the QTL for vertebral and teat numbers and provided useful molecular markers for breeding in the Beijing Black Pig population.
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