Structurally diverse phthalides from fibrous roots of Ligusticum chuanxiong Hort. and their biological activities
文献类型： 外文期刊
作者： Tan, Yu-Zhu 1 ; Yan, Hong-Ling 1 ; Liu, Yun-Yun 1 ; Yan, Yong-Ming 2 ; Wang, Li 3 ; Qiao, Ji-Xu 1 ; Wu, Jing 1 ; Tian, Yin 1 ; Peng, Cheng 1 ;
作者机构： 1.Chengdu Univ Tradit Chinese Med, Sch Pharm, Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
2.Shenzhen Univ, Inst Inheritance Based Innovat Chinese Med, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China
3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr,Minist Agr & Rura, Shenzhen 518120, Guangdong, Peoples R China
关键词： Ligusticum chuanxiong; Phthalides; Structure elucidation; Biological activities; Structure-activity relationships
期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）
ISSN： 0367-326X
年卷期： 2024 年 175 卷
页码：
收录情况： SCI
摘要： Falonolide A (1) and B (2), two novel polyyne hybrid phthalides resulting from unprecedented carbon skeleton polymerized by Z-ligustilide and falcarindiol, along with six new related phthalides (3-8), were isolated from Ligusticum chuanxiong Hort. Their structures were elucidated by spectroscopic analysis, computer-assisted structure elucidation (CASE) analysis, DP4+ probability analysis and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway for 1-8 was proposed, and the production mechanism of 2 was revealed by density functional theory (DFT) method. Compounds 4 and 6 exhibited significant vasodilatory activity with EC50 of 8.00 +/- 0.86 and 6.92 +/- 1.02 mu M, respectively. Compound 4 also displayed significant inhibitory effect of NO production with EC50 value of 8.82 +/- 0.30 mu M. Based on the established compounds library, structure-activity relationship analysis of phthalides was explored to provide insights into the drug development of vasodilators and anti-flammatory
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