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Optimizing the Size of Zr-Based Metal-Organic Frameworks for Enhanced Anticancer Efficacy

文献类型： 外文期刊

作者： Cheng, Zan 1 ; Yu, Mei 1 ; Wan, Yilong 2 ; Xiang, Huandong 2 ; Wei, Haoran 2 ; Zu, Xu 2 ; Li, Xin 2 ; Zhang, Ruiting 1 ; Li, Fangshu 1 ; Wang, Shanshan 1 ; She, Yongxin 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Beijing 100081, Peoples R China

2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

3.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100049, Peoples R China

关键词： metal-organic frameworks; UiO-67; drug delivery; cellular internalization; anticancer

期刊名称：NANOMATERIALS （ 影响因子：4.3； 五年影响因子：4.7 ）

ISSN：

年卷期： 2025 年 15 卷 11 期

页码：

收录情况： SCI

摘要： Metal-organic frameworks (MOFs) have great potential for drug delivery systems due to their tunnel pore size, structural versatility, and high surface area. Among them, UiO-67 have recently attracted substantial attention as functional nanocarriers for effective delivery of small molecule chemical drugs. However, the influence of the size on cellular uptake of UiO-67 remains ambiguous. Here, we use polyvinyl pyrrolidone (PVP) as the capping agent of UiO-67 to synthesize spherical Zr-based MOFs with various diameters, including 40 nm, 60 nm, and 120 nm. The highest cellular uptake is observed in the case of Zr-based MOFs with a diameter of 40 nm (PU40 MOFs). Moreover, doxorubicin can be loaded into the inner pores of PU40 MOF via pi-pi and electrostatic interactions (DPU40 MOFs), with a loading capacity of 82 wt%, and gradually released under acidic conditions. In vitro, the resulting DPU40 MOFs can be internalized by cancer cells more effectively, thereby enhancing the delivery of doxorubicin into cancer cells. Ultimately, this results in enhanced antitumor efficacy toward 4T1, Hs 578T, and MCF-7 cells. Our findings indicate that approximately 40 nm may be the optimum diameter for the special Zr-based MOFs to be internalized by cells more effectively, providing potent potential nanocarriers for drug delivery.

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