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Iturin and fengycin lipopeptides inhibit pathogenic Fusarium by targeting multiple components of the cell membrane and their regulative effects in wheat

文献类型： 外文期刊

作者： Yuan, Qing-Song 1 ; Yang, Peng 1 ; Liu, Yi-Ke 4 ; Tabl, Karim M. 1 ; Guo, Mao-Wei 1 ; Zhang, Jing-Bo 1 ; Wu, Ai-Bo 7 ; Liao, Yu-Cai 1 ; Huang, Tao 8 ; He, Wei-Jie 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Plant Sci & Technol, Wuhan 430070, Peoples R China

2.Guizhou Univ Tradit Chinese Med, Resource Inst Chinese & Ethn Mat Med, Guiyang 550025, Peoples R China

3.Jiangsu Ruihua Agr Sci & Technol Co Ltd, Suqian 223800, Peoples R China

4.Hubei Acad Agr Sci, Inst Food Crops, Key Lab Crop Mol Breeding, Hubei Key Lab Food Crop Germplasm & Genet Improvem, Wuhan 430064, Peoples R China

5.Alexandria Univ, Fac Agr Saba Basha, Agr Bot Dept, Alexandria 21531, Egypt

6.Chinese Acad Agr Sci, Grassland Res Inst, Hohhot 010000, Peoples R China

7.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, SIBS UGENT SJTU Joint Lab Mycotoxin Res,CAS Key La, Shanghai 200031, Peoples R China

8.Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Peoples R China

关键词： antagonism; Fusarium graminearum; Fusarium head blight; induced systemic resistance; iturin and fengycin lipopeptides; plant growth regulation

期刊名称：JOURNAL OF INTEGRATIVE PLANT BIOLOGY （ 影响因子：9.3； 五年影响因子：10.8 ）

ISSN： 1672-9072

年卷期： 2025 年 67 卷 8 期

页码：

收录情况： SCI

摘要： Biocontrol microorganisms and their derived metabolites with antagonistic activity represent promising alternatives to chemical fungicides in managing plant pathogens. The lipopeptides (LPs) iturin and fengycin derived from Bacillus amyloliquefaciens S76-3 exhibit highly inhibitory effects against pathogenic fungi, especially Fusarium graminearum (Fg), the primary pathogen causing Fusarium head blight (FHB) in cereals. However, the specific target of iturin and fengycin in Fg and the underlying mechanism of antagonistic activity remain unclear. Here, global transcriptome sequencing, combined with both genetic and chemical approaches, demonstrates that the LPs exhibit antagonism toward Fg by binding to multiple components in the cell membrane of Fg cells, including ergosterol, phospholipids, glycosylphosphatidylinositol, and ankyrin. Lipopeptides result in cell swelling by inducing cell wall remodeling and osmotic substance glycerol synthesis mediated by cell wall integrity and high-osmolarity glycerol signaling pathways. Furthermore, we found that LPs can activate the induced systemic resistance in wheat against FHB and deoxynivalenol accumulation. Additionally, LPs were able to promote wheat growth by regulating auxin, cytokinin, and gibberellin signaling pathways while also delaying seed germination through the stimulation of abscisic acid and ethylene signaling pathways. These findings advance knowledge on the underlying mechanism of iturin and fengycin antagonistic activity and provide a new avenue for developing agricultural and clinical broad-spectrum antifungal agents and identifying plant growth regulators in the future.

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