Black Tea Aqueous Extract Extends Yeast Longevity via Antioxidant Gene Activation: Transcriptomic Analysis of Anti-Aging Mechanisms
文献类型： 外文期刊
作者： Li, Jie 1 ; Chen, Qiyang 2 ; Xiao, Fuliang 1 ; Yang, Juan 1 ; Zhou, Sijia 3 ; Tang, Min 1 ; Hou, Yujia 1 ; Zhai, Xiuming 1 ;
作者机构： 1.Chongqing Acad Agr Sci, Chongqing, Peoples R China
2.Southwest Univ Sci & Technol, Engn Res Ctr Biomass Mat, Sch Life Sci & Agri Forestry, Minist Educ, Mianyang, Peoples R China
3.Chongqing Univ, Jiangjin Hosp, Chongqing, Peoples R China
关键词：
anti-aging; antioxidant capacity; black tea; chronological lifespan;
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.8； 五年影响因子：4.5 ）
ISSN： 2048-7177
年卷期： 2025 年 13 卷 7 期
页码：
收录情况： SCI
摘要： Although tea polyphenols have antiaging potential, the molecular interplay between black tea components and cellular longevity remains unclear. This study has pioneered a dual approach combining Saccharomyces cerevisiae lifespan assays with comprehensive transcriptomics to dissect how black tea aqueous extract (BTAE) extends the chronological lifespan (CLS). Remarkably, BTAE induced a dose-dependent lifespan extension (34.6% maximum at 40 mu g/mL), coupled with a 62% reduction in reactive oxygen species (ROS) accumulation and enhanced superoxide dismutase/catalase/ascorbate peroxidase (SOD/CAT/APX) enzyme activities-hallmarks of antioxidant system activation. Transcriptomic profiling revealed the action mechanism of BTAE: (1) upregulation of oxidative defense arsenals (SOD1/2, CTA1, and CTT1) and mitochondrial efficiency genes (COX10), and (2) strategic downregulation of apoptosis triggers (NMA111 and AIF1) and aging accelerators (MTH1 and HSPs). Additionally, we have identified novel targets including the OLE1-mediated membrane protection pathway and IRE1-dependent proteostatic regulation as key longevity switches. These findings establish BTAE as a multi-target anti-aging modulator and offer a roadmap for translating yeast discovery into mammalian aging interventions.
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