文献类型： 外文期刊
作者： Tao, L. 1 ; He, X. Y. 1 ; Jiang, Y. T. 2 ; Lan, R. 2 ; Li, M. 3 ; Li, Z. M. 3 ; Yang, W. F. 3 ; Hong, Q. H. 2 ; Chu, M. X. 1 ;
作者机构： 1.Chinese Acad Agr Sci, Key Lab Anim Genet Breeding & Reprod, Minist Agr & Rural Affairs, Inst Anim Sci, Beijing 100193, Peoples R China
2.Yunnan Anim Sci & Vet Inst, Kunming 650224, Yunnan, Peoples R China
3.Annoroad Gene Technol Co Ltd, Beijing 100176, Peoples R China
关键词： extended haplotype homozygosity; genome-wide association study; goat; kidding number; runs of homozygosity; signatures of selection
期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）
ISSN： 0268-9146
年卷期： 2020 年 51 卷 6 期
页码：
收录情况： SCI
摘要： Intensive artificial selection has been imposed in Yunshang black goats, the first black specialist mutton goat breed in China, with a breeding object of improving reproductive performance, which has contributed to reshaping of the genome including the characterization of SNP, ROH and haplotype. However, variation in reproductive ability exists in the present population. A WGS was implemented in two subpopulations (polytocous group, PG, and monotocous group, MG) with evident differences of litter size. Following the mapping to reference genome, and SNP calling and pruning, three approaches - GWAS, ROH analysis and detection of signatures of selection - were employed to unveil candidate genes responsible for litter size. Consequently, 12 candidate genes containingOSBPL8with the minimumP-value were uncovered by GWAS. Differences were observed in the pattern of ROH between two subpopulations that shared similar low inbreeding coefficients. Two ROH hotspots and 12 corresponding genes emerged from ROH pool association analysis. Based on thenS(L)statistic, 15 and 61 promising genes were disclosed under selection for MG and PG respectively. Of them, some promising genes participate in ovarian function (PPP2R5C,CDC25A,ESR1,RPS26andSERPINBs), seasonal reproduction (DIO3,BTG1andCRYM) and metabolism (OSBPL8,SLC39A5andSERPINBs). Our study pinpointed some novel promising genes influencing litter size, provided a comprehensive insight into genetic makeup of litter size and might facilitate selective breeding in goats.
- 相关文献
作者其他论文 更多>>
-
CO2 Enrichment Improves the Drought Resistance of Cucumber Seedlings by Improving Antioxidant Capacity and Sucrose Metabolism
作者：Li, S. H.;Li, Y. M.;Li, M.;He, X. R.;Jiang, W. L.;Liu, B. B.;Li, Q. M.
关键词：Cucumis sativus; cucumber; enriched [CO2]; drought stress; membrane lipid peroxidation; sucrose metabolism; resistance
-
Genome-wide association study and inbreeding depression on body size traits in Qira black sheep (Ovis aries)
作者：Tao, L.;Liu, Y. F.;Zhang, H.;Li, H. Z.;Zhao, F. P.;Wang, F. Y.;Zhang, R. S.;Di, R.;Chu, M. X.;Liu, Y. F.
关键词：body conformation; genome-wide association study; inbreeding depression; sheep; tail length
-
Genome-wide association study of body weight and conformation traits in neonatal sheep
作者：Tao, L.;He, X. Y.;Chu, M. X.;Pan, L. X.;Wang, J. W.;Gan, S. Q.
关键词：birth weight; body conformation; candidate gene; GWAS; sheep; SNPs
-
Isolation and sequence analysis of the complete VP2 gene of canine parvovirus from Chinese domestic pets and determination of the pathogenesis of these circulating strains in beagles
作者：Chen, M. R.;Guo, X. Y.;Wang, Z. Y.;Jiang, Y. T.;Yuan, W. F.;Xin, T.;Hou, S. H.;Song, T. Q.;Lin, W. D.;Zhu, H. F.;Jia, H.;Chen, M. R.
关键词：canine parvovirus; molecular epidemiology; phylogenetic analysis; pathogenesis
-
Phospholipase C signaling is involved in porcine reproductive and respiratory syndrome virus infection in cell cultures
作者：Yuan, W. F.;Gao, X. T.;Jia, H.;Zhu, H. F.;Xin, T.;Sui, X. K.;Li, M.;Hou, S. H.;Guo, X. Y.;Chen, Q.;Chen, Q.;Zheng, Z. M.
关键词：PRRSV; U73122; phospholipase C; PLC gamma-1
-
Changes in carbohydrate and protein fractions during ensiling of alfalfa treated with previously fermented alfalfa juice or lactic acid bacteria inoculants
作者：Tao, L.;Zhang, N-F;Si, B-W.;Tu, Y.;Ma, T.;Diao, Q-Y.;Zhou, H.
关键词：additive;alfalfa silage;CNCPS;dynamics;nutritive value
-
Real-time variations in body temperature of laying hens with increasing ambient temperature at different relative humidity levels
作者：Chang, Y.;Wang, X. J.;Feng, J. H.;Zhang, M. H.;Zhang, S. S.;Zhou, Y.;Diao, H. J.;Li, M.;Peng, Q. Q.;Li, X.
关键词：core temperature; increasing ambient temperature; laying hen; relative humidity; surface temperature
