Terpenoids From the Coral-Derived Fungus Trichoderma harzianum (XS-20090075) Induced by Chemical Epigenetic Manipulation
文献类型： 外文期刊
作者： Shi, Ting 1 ; Shao, Chang-Lun 1 ; Liu, Yang 3 ; Zhao, Dong-Lin 5 ; Cao, Fei 6 ; Fu, Xiu-Mei 1 ; Yu, Jia-Yin 1 ; Wu, Jing- 1 ;
作者机构： 1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
3.Justus Liebig Univ Giessen, Inst Insect Biotechnol, Giessen, Germany
4.Fraunhofer Inst Mol Biol & Appl Ecol, Dept Bioresources, Giessen, Germany
5.Chinese Acad Agr Sci, Marine Agr Res Ctr, Tobacco Res Inst, Qingdao, Peoples R China
6.Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding, Peoples R China
7.Ocean Univ China, Inst Evolut & Marine Biodivers, Qingdao, Peoples R China
关键词： Coral-derived fungus; Trichoderma harzianum; Chemical epigenetic manipulation; Diterpenoids; Sesquiterpenoids
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）
ISSN： 1664-302X
年卷期： 2020 年 11 卷
页码：
收录情况： SCI
摘要： The soft coral-derived fungus Trichoderma harzianum (XS-20090075) was found to be a potential strain to produce substantial new compounds in our previous study. In order to explore its potential to produce more metabolites, chemical epigenetic manipulation was used on this fungus to wake its sleeping genes, leading to the significant changes of its secondary metabolites by using a histone deacetylase (HDAC) inhibitor. The most obvious difference was the original main products harziane diterpenoids were changed into cyclonerane sesquiterpenoids. Three new terpenoids were isolated from the fungal culture treated with 10 mu M sodium butyrate, including cleistanthane diterpenoid, harzianolic acid A (1), harziane diterpenoid, harzianone E (2), and cyclonerane sesquiterpenoid, 3,7,11-trihydroxy-cycloneran (3), together with 11 known sesquiterpenoids (4-14). The absolute configurations of 1-3 were determined by single-crystal X-ray diffraction, ECD and OR calculations, and biogenetic considerations. This was the first time to obtain cleistanthane diterpenoid and africane sesquiterpenoid from genus Trichoderma, and this was the first chlorinated cleistanthane diterpenoid. These results demonstrated that the chemical epigenetic manipulation should be an efficient technique for the discovery of new secondary metabolites from marine-derived fungi.
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