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Multiple stresses induced by chronic exposure to flupyradifurone affect honey bee physiological states

文献类型： 外文期刊

作者： Chen, Jin 1 ; Liu, Yong-Jun 1 ; Wang, Qiang 1 ; Zhang, Li 1 ; Yang, Sa 1 ; Shi, Min 2 ; Gao, Jing 1 ; Dai, Ping-Li 1 ; Wu, Yan-Yan 1 ;

作者机构： 1.Chinese Acad Agr Sci, State Key Lab Resource Insects, Inst Apicultural Res, Beijing 100093, Peoples R China

2.Shanghai Normal Univ, Coll Life Sci, Dev Ctr Plant Germplasm Resources, Shanghai 201418, Peoples R China

关键词： Flupyradifurone; Apoptosis; Olfactory behavior; Oxidative stress; Immunity; Detoxification

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：8.2； 五年影响因子：8.6 ）

ISSN： 0048-9697

年卷期： 2024 年 935 卷

页码：

收录情况： SCI

摘要： Flupyradifurone (FPF) has been reported to have a potential risk to terrestrial and aquatic ecosystems. In the present study, the effects of chronic FPF exposure on bees were systematically investigated at the individual behavioral, tissue, cell, enzyme activity, and the gene expression levels. Chronic exposure (14 d) to FPF led to reduced survival (12 mg/L), body weight gain (4 and 12 mg/L), and food utilization efficiency (4 and 12 mg/L). Additionally, FPF exposure (12 mg/L) impaired sucrose sensitivity and memory of bees. Morphological analysis revealed significant cellular and subcellular changes in brain neurons and midgut epithelial cells, including mitochondrial damage, nuclear disintegration, and apoptosis. FPF exposure (4 and 12 mg/L) led to oxidative stress, as evidenced by increased lipid peroxidation and alterations in antioxidant enzyme activity. Notably, gene expression analysis indicated significant dysregulation of apoptosis, immune, detoxification, sucrose responsiveness and memory -related genes, suggesting the involvement of different pathways in FPF-induced toxicity. The multiple stresses and potential mechanisms described here provide a basis for determining the intrinsic toxicity of FPF.

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